A0A2R2Z2I5 · A0A2R2Z2I5_SINWO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      cox1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A2R2Z2I5

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane46-72Helical
Transmembrane84-102Helical
Transmembrane122-146Helical
Transmembrane167-194Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503376636619-219Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,258
  • Last updated
    2018-06-20 v1
  • Checksum
    B0DA03262AB30D66
TLYLLLALWSGLIGLALSLLIRAELGQPGSLLGDDQLYNVIVTAHAFMMIFFLVMPMMIGGFGNWLIPLMIGAPDMAFPRLNNLSFWLLVPALFLLLSSSLVESGVGTGWTVYPPLSGNVAHSGASVDLAIFSLHLAGASSILGAVNFISTVGNMRSPGLVAERIPLFVWAVTVTAILLVAALPVLAGAITMLLTDRNLNTSFFDPTGGGDPILYMHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY978735
EMBL· GenBank· DDBJ
ARR73552.1
EMBL· GenBank· DDBJ
Genomic DNA
KY978736
EMBL· GenBank· DDBJ
ARR73553.1
EMBL· GenBank· DDBJ
Genomic DNA
KY978738
EMBL· GenBank· DDBJ
ARR73555.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809929
EMBL· GenBank· DDBJ
QHI06194.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809930
EMBL· GenBank· DDBJ
QHI06195.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809931
EMBL· GenBank· DDBJ
QHI06196.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809932
EMBL· GenBank· DDBJ
QHI06197.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809933
EMBL· GenBank· DDBJ
QHI06198.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809934
EMBL· GenBank· DDBJ
QHI06199.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809935
EMBL· GenBank· DDBJ
QHI06200.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809936
EMBL· GenBank· DDBJ
QHI06201.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809937
EMBL· GenBank· DDBJ
QHI06202.1
EMBL· GenBank· DDBJ
Genomic DNA
MN809938
EMBL· GenBank· DDBJ
QHI06203.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013156
EMBL· GenBank· DDBJ
QLC48296.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013162
EMBL· GenBank· DDBJ
QLC48302.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013163
EMBL· GenBank· DDBJ
QLC48303.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013167
EMBL· GenBank· DDBJ
QLC48307.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013168
EMBL· GenBank· DDBJ
QLC48308.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013172
EMBL· GenBank· DDBJ
QLC48312.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013173
EMBL· GenBank· DDBJ
QLC48313.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013175
EMBL· GenBank· DDBJ
QLC48315.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013177
EMBL· GenBank· DDBJ
QLC48317.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013178
EMBL· GenBank· DDBJ
QLC48318.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013179
EMBL· GenBank· DDBJ
QLC48319.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013180
EMBL· GenBank· DDBJ
QLC48320.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013181
EMBL· GenBank· DDBJ
QLC48321.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013182
EMBL· GenBank· DDBJ
QLC48322.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013183
EMBL· GenBank· DDBJ
QLC48323.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013185
EMBL· GenBank· DDBJ
QLC48325.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013186
EMBL· GenBank· DDBJ
QLC48326.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013190
EMBL· GenBank· DDBJ
QLC48330.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013191
EMBL· GenBank· DDBJ
QLC48331.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013192
EMBL· GenBank· DDBJ
QLC48332.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013193
EMBL· GenBank· DDBJ
QLC48333.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013196
EMBL· GenBank· DDBJ
QLC48336.1
EMBL· GenBank· DDBJ
Genomic DNA
MT013197
EMBL· GenBank· DDBJ
QLC48337.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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