A0A2R2Z2I5 · A0A2R2Z2I5_SINWO
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Unioninae > Sinanodonta
Accessions
- Primary accessionA0A2R2Z2I5
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 46-72 | Helical | |||
Transmembrane | 84-102 | Helical | |||
Transmembrane | 122-146 | Helical | |||
Transmembrane | 167-194 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5033766366 | 19-219 | Cytochrome c oxidase subunit 1 | ||
Structure
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,258
- Last updated2018-06-20 v1
- ChecksumB0DA03262AB30D66
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 219 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY978735 EMBL· GenBank· DDBJ | ARR73552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY978736 EMBL· GenBank· DDBJ | ARR73553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY978738 EMBL· GenBank· DDBJ | ARR73555.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809929 EMBL· GenBank· DDBJ | QHI06194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809930 EMBL· GenBank· DDBJ | QHI06195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809931 EMBL· GenBank· DDBJ | QHI06196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809932 EMBL· GenBank· DDBJ | QHI06197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809933 EMBL· GenBank· DDBJ | QHI06198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809934 EMBL· GenBank· DDBJ | QHI06199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809935 EMBL· GenBank· DDBJ | QHI06200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809936 EMBL· GenBank· DDBJ | QHI06201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809937 EMBL· GenBank· DDBJ | QHI06202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN809938 EMBL· GenBank· DDBJ | QHI06203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013156 EMBL· GenBank· DDBJ | QLC48296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013162 EMBL· GenBank· DDBJ | QLC48302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013163 EMBL· GenBank· DDBJ | QLC48303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013167 EMBL· GenBank· DDBJ | QLC48307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013168 EMBL· GenBank· DDBJ | QLC48308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013172 EMBL· GenBank· DDBJ | QLC48312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013173 EMBL· GenBank· DDBJ | QLC48313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013175 EMBL· GenBank· DDBJ | QLC48315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013177 EMBL· GenBank· DDBJ | QLC48317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013178 EMBL· GenBank· DDBJ | QLC48318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013179 EMBL· GenBank· DDBJ | QLC48319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013180 EMBL· GenBank· DDBJ | QLC48320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013181 EMBL· GenBank· DDBJ | QLC48321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013182 EMBL· GenBank· DDBJ | QLC48322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013183 EMBL· GenBank· DDBJ | QLC48323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013185 EMBL· GenBank· DDBJ | QLC48325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013186 EMBL· GenBank· DDBJ | QLC48326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013190 EMBL· GenBank· DDBJ | QLC48330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013191 EMBL· GenBank· DDBJ | QLC48331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013192 EMBL· GenBank· DDBJ | QLC48332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013193 EMBL· GenBank· DDBJ | QLC48333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013196 EMBL· GenBank· DDBJ | QLC48336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT013197 EMBL· GenBank· DDBJ | QLC48337.1 EMBL· GenBank· DDBJ | Genomic DNA |