A0A2P8ANL7 · A0A2P8ANL7_9ACTN

  • Protein
    Lipoprotein signal peptidase
  • Gene
    lspA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

121220406080100120140160180200
TypeIDPosition(s)Description
Active site151
Active site170

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      B0E53_06044

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MH33
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micromonosporales > Micromonosporaceae > Micromonospora

Accessions

  • Primary accession
    A0A2P8ANL7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane94-112Helical
Transmembrane119-139Helical
Transmembrane159-183Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-30Disordered
Region193-212Disordered

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    22,073
  • Last updated
    2018-05-23 v1
  • Checksum
    94C6173AFDA165ED
MTATVASVDGEQMIAAPPAGSGTAGPGTGTPRRKATGLLLGVALTSLVADLVTKQLALSELTGRGPVSLLGGAVYLSLTRNSGAAWSIGSGHTWVFPLITIGVVAWIAWMALRLRSLPWAVSLGLVLGGALGNLTDRIFRAPGHFVGHVVDMVSLFDPYGQVWPVFNLADSSLVCGVLLAVFLELTGRQRDGSRATAERSGDETPAEQRERA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUYZ01000317
EMBL· GenBank· DDBJ
PSK62059.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp