A0A2P6WAS4 · A0A2P6WAS4_9EURY

Function

function

Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site79-83GMP (UniProtKB | ChEBI)
Binding site80Mn2+ 1 (UniProtKB | ChEBI)
Binding site111Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionRNA ligase (ATP) activity
Molecular FunctionRNA ligase (GTP) activity
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-splicing ligase RtcB
  • EC number
  • Alternative names
    • 3'-phosphate/5'-hydroxy nucleic acid ligase

Gene names

    • ORF names
      BRC26_01165

Organism names

Accessions

  • Primary accession
    A0A2P6WAS4

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the RtcB family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    162
  • Mass (Da)
    18,360
  • Last updated
    2018-05-23 v1
  • Checksum
    E442259FD268AAFD
MYSKIPVGLGKGGYLNTDKEDLREILDKGMEWMLENGHAHEEDLRRCEENGKLPGDYRKVPDDAIKRGLNQVGSLGSGNHFMEVQIVGEVFDEEKAEAYGLEANQVVIMIHSGSRGLGHETCTKYLRRFEKEYPEIAESIPEKNLIYAPIEDEPAQDYKKAM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue162

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PXPB01000073
EMBL· GenBank· DDBJ
PSH02320.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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