A0A2P6U3H1 · A0A2P6U3H1_CHLSO
- ProteinGPI inositol-deacylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2898 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
Catalytic activity
- 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 2-isopropylmalate synthase activity | |
Molecular Function | hydrolase activity, acting on ester bonds | |
Molecular Function | N-carbamoylputrescine amidase activity | |
Biological Process | L-leucine biosynthetic process | |
Biological Process | polyamine biosynthetic process | |
Biological Process | protein transport |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGPI inositol-deacylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Chlorophyta > core chlorophytes > Trebouxiophyceae > Chlorellales > Chlorellaceae > Chlorella clade > Chlorella
Accessions
- Primary accessionA0A2P6U3H1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1130-1153 | Helical | ||||
Sequence: MWPAVGLTALLILLLITALTAGLL | ||||||
Transmembrane | 1672-1692 | Helical | ||||
Sequence: AVGVTVLLSLLLITALTAGLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-285 | CN hydrolase | ||||
Sequence: VTVAATQMACTWDIEDNLRKAEGLVRQAAAAGAQIILLQELFEAPYFCQEQKPEYYRLAKPLEDNPLIQRFAKLAAELGVVLPISFFERAGNAHFNSIVVADADGSIVGHYRKSHIPDGPGYQEKFYFSPGDTGFKVFQTRYADIGVLICWDQWFPEGARCAALQGAEVLFYPTAIGSEPPNPSYSSYPHWARVMQGHAGANMVPLVASNRIGTETFEHSHITFYGGSFIAGPSGEIVAQAGARGKQANGGIDPEPEQQEGFVTATFDL | ||||||
Domain | 353-626 | Pyruvate carboxyltransferase | ||||
Sequence: VRIFDTTLRDGEQSPGCTLTSKEKLAIAKQLAKLGVDIIEAGFPVASPDDFEGVRAIAQEVGNTVRDDGYVPAICAFARPLESDLQRAWDAVKFARYPRVNFFIATSEIHMKHKLRMSEDQVTQAVIDAITFLRSLGCNDIEFTPEDAGRSDPAYLYEVLGEAVKAGATTLNITDTVGYCLPHEFLELMRGIKAHTPGIDSVVLSAHCHNDLGQAASNTLMAAVAGARQLEVTINGIGERAGNASHEEVVMALALRGERLLGGLRTGIETVNLS | ||||||
Region | 940-960 | Disordered | ||||
Sequence: IDHSSGLPTPGNNGSRSSAAA | ||||||
Compositional bias | 1476-1491 | Polar residues | ||||
Sequence: IDQASGPPTPGASGSR | ||||||
Region | 1476-1499 | Disordered | ||||
Sequence: IDQASGPPTPGASGSRSSAAAAAA |
Sequence similarities
Belongs to the GPI inositol-deacylase family.
Belongs to the carbon-nitrogen hydrolase superfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,898
- Mass (Da)309,705
- Last updated2018-05-23 v1
- Checksum3552B4FDFA54CD95
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2P6U3H9 | A0A2P6U3H9_CHLSO | C2E21_0876 | 2911 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1476-1491 | Polar residues | ||||
Sequence: IDQASGPPTPGASGSR |
Keywords
- Technical term