A0A2P6NGP8 · A0A2P6NGP8_9EUKA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

110361002003004005006007008009001,000
TypeIDPosition(s)Description
Active site782Proton donor
Binding site782-786AMP (UniProtKB | ChEBI)
Binding site786Zn2+ 1 (UniProtKB | ChEBI)
Binding site822Zn2+ 1 (UniProtKB | ChEBI)
Binding site823AMP (UniProtKB | ChEBI)
Binding site823Zn2+ 2 (UniProtKB | ChEBI)
Binding site823Zn2+ 1 (UniProtKB | ChEBI)
Binding site934AMP (UniProtKB | ChEBI)
Binding site934Zn2+ 1 (UniProtKB | ChEBI)
Binding site985AMP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCOP9 signalosome
Cellular Componentmembrane
Molecular Function3',5'-cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Biological Processprotein deneddylation
Biological Processsignal transduction
Biological Processsorocarp development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • ORF names
      PROFUN_09790

Organism names

  • Taxonomic identifier
  • Strain
    • Jena
  • Taxonomic lineage
    Eukaryota > Amoebozoa > Evosea > Variosea > Cavosteliida > Cavosteliaceae > Planoprotostelium

Accessions

  • Primary accession
    A0A2P6NGP8

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane401-422Helical
Transmembrane428-444Helical
Transmembrane456-476Helical
Transmembrane482-501Helical
Transmembrane508-530Helical
Transmembrane550-570Helical

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, coiled coil.

TypeIDPosition(s)Description
Domain19-157MPN
Region363-384Disordered
Coiled coil581-615
Domain706-1028PDEase

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the peptidase M67A family. CSN6 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,036
  • Mass (Da)
    117,310
  • Last updated
    2018-05-23 v1
  • Checksum
    A4E2CB0D1A273B66
MDVETKNNILVEKSSTLEIKLHPLVIINISDHWTRAKVQNNVKNPRVVGAIVGIQNGRTVEIFNSYELAYKEEGSLVNIDLEYLMMKSEQFKKVFATYDFLGWYSTGSGVTQDDLTTQKQLSEINESPLYLLLDTVAASRPETKDIPISIMESEIRIISDQPTMFFSKVPYQIESGEAERISVDHIARITPSGDSNTSQISTHLTGIHNSIGMLATRLRILKSFLEAVKSGKIAADPGLLRQLGSLCNQLPALHSDELKNDFIVEFNDSLLITYLASITKGTNGMNEMIDKFNVVYEKQKRKGNPLYYCGPKVLITEPSIVTEDSSSSEEMGDDHPQTIDDGTKGEIALELKLPKRRSMRRLNSRTSNMNDFTPKSSGSRPTTAPSSLYAMQSAGTLKGPVLIQSAGMYCILTLIIASAELLQWAPNIRLITFVPYFMIFYVITEACRLASLLGDVWEAVLPFYATLIPFAILVFLSREAHILVTVLFFSYVMIIYLQSGLMSLQIHLMIYILSFLFIYVAAVCVMMVWYRDATGLDFKLGRILDPPINWQQELTFVCSLAILGIGFLFLEQFVKLYANTLLDRSHKIQTLEQETEELKKEITKYKQEKDDIDLDAPIQKVISVLRNMANESDEDTREQLFFVIKTLSSNKLYAPELNFEEKSVDGEVASFIQNLIEDGKEDKHTENKLAVLEKRTGKIARFLPLVDEGTEKRIEAGLQRIEDWEFNIFEMTDLTEGRPLFATGLALFNRHDFIRKFNINESRLKHFLTVIEDGYDITNPYHNAIHASDVLHALNFFIVKGGLSAYITELDVFSAVIAAIVHDYMHPGLNNAYQINTQSELAVRYNDRSVLESFHVASAFKVLYEDSNNIFSGLTEAQRKEARETIVTMVMATDMAQHFDLLGRFKSKIAGQGFDPKDRKDRLLLLQIAIKCADISNPMRPQAMCNTWAHRVLSEFYKQGDMERKQGLPVSAFMDRGKPAEAKCQIGFIDFIVGPIFEVWTSFLPEVGKLMVNLEQNRIYWKNAMEQNSIQEVGGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MDYQ01000089
EMBL· GenBank· DDBJ
PRP83111.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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