A0A2P6MHI7 · A0A2P6MHI7_ALKUR

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site73Na+ (UniProtKB | ChEBI); structural
Binding site76Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • ORF names
      C6I21_07470

Organism names

Accessions

  • Primary accession
    A0A2P6MHI7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-55Helical
Transmembrane62-83Helical
Transmembrane95-119Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    126
  • Mass (Da)
    12,512
  • Last updated
    2018-05-23 v1
  • Checksum
    183011F136C8EE0A
MQIHVLAAVFAGGALGTLLRVGLNTLFIEASFPYATMTANVTGSFLLGAVTALALTKNIPLWLKAGAGAGFCGGFTTMATLALDTVVTSGLHGGAVLLYLGGSAVGGIAAAAAGFFLCYRRGGKSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PVNS01000006
EMBL· GenBank· DDBJ
PRO65731.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp