A0A2P4WXP4 · A0A2P4WXP4_9STRA

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      PHPALM_37358

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • sbr112.9
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora

Accessions

  • Primary accession
    A0A2P4WXP4

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane55-72Helical
Transmembrane92-112Helical
Transmembrane124-141Helical
Transmembrane147-172Helical
Transmembrane184-211Helical
Transmembrane217-240Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-34Disordered
Domain54-246Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    246
  • Mass (Da)
    26,971
  • Last updated
    2018-05-23 v1
  • Checksum
    5B88BEA1D0054AD2
MAPKQKESTDPSELTPLVYDASPNGDGGALTPPRSPLQRAPVWQFWRTTSPPHRFYLLLLMSFIPFGGHFVKNGMSSLEQLMLDDPDFPITNTMYGALLSAVSVPNMFLPLLGGRLLDKSGHRSIRFFLAWICVGQAIFAIGMELKLYWLALFGRVFFGVGEGSVVVGARVFIASWFRNKELTFAMGVSVAVTNVSKMLAKATVAPIALYFGGYVQALWYGVAVCVASALVGVLVCHYTLNLKRIV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue246

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NCKW01020383
EMBL· GenBank· DDBJ
POM58049.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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