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A0A2P4TFJ2 · A0A2P4TFJ2_BAMTH

Function

function

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular Functionmethyltransferase activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcell fate commitment
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PR domain zinc finger protein 1
  • EC number

Gene names

    • ORF names
      CIB84_001105

Organism names

  • Taxonomic identifier
  • Strain
    • RTK389
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Perdicinae > Bambusicola

Accessions

  • Primary accession
    A0A2P4TFJ2

Proteomes

Subcellular Location

Interaction

Subunit

Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain82-198SET
Region254-279Disordered
Compositional bias322-363Polar residues
Region322-376Disordered
Domain572-599C2H2-type
Domain600-627C2H2-type
Domain628-655C2H2-type
Domain656-683C2H2-type

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    822
  • Mass (Da)
    92,368
  • Last updated
    2018-05-23 v1
  • MD5 Checksum
    C40ABE37D839BD0241B44F5BAB56B638
MRIKGCFLIFQAATQCSSDAVSFKNLVKGREWTMKMDMEDADMTLWTEADFEEKCTYIVNDHPWDPSADGGTLTQAEASLPRNLTFKYASNCKEVTGVISKEYIPKGTRFGPLVGEIYTSDTVPKNANRKYFWRIYSSGELHHFIDGFNEDKSNWMRYVNPGYSVQEQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPSSRELTMMNLTQTHVNPKQHSADKDELYQKSVPKKEHSVKEILKMESSPPKGKDFFQTNISPVTPEKDLDDLRKNYSPERCFFPRVVYPIRPHIPEDYLKASLAYGMDRPSYITHSPIQSSTTPSPSGRSSPDQSLKSSSPHSSPGVTVSPLAPTSQEHREPYPYLNGSYGSEGLGSYPGYAPSSHLPSAFLPSYNPHYPKFLLPPFNMSCNNLSALNNINGINNFNLFPRMYPLYGNLLSGGSLSHHMLNPTTLPSSLPSEGGRRLLQPDHPRDFLIPAPNSAFSITGAAASMKDKPCSPTSGSPTAGTAASSEHIMQPKPTSVVLAATGGEEAMNLIKSKRNVTGYKTLPYPLKKQNGKIKYECNVCSKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKLCPAKFTQFVHLKLHKRLHTRERPHKCIHCHKSYIHLCSLQVHLKGNCPVAPASGLSMEDLNRINEEIEKFDISDNADKLEEVEDNIDLTSIVEKDILTVLRREMEGANLKVSLQRNLGNGLISSGCNLYESSDMSIMKLPHSHPLPLLPVKVKQETVEPMDP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias322-363Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PPHD01000756
EMBL· GenBank· DDBJ
POI35143.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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