A0A2P1M5J2 · A0A2P1M5J2_BCHK9

Function

function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell Golgi apparatus
Cellular Componentribonucleoprotein complex
Cellular Componentviral nucleocapsid
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoprotein
  • Alternative names
    • Nucleocapsid protein
      (NC
      ; Protein N
      )

Gene names

    • Name
      N

Organism names

Accessions

  • Primary accession
    A0A2P1M5J2

Subcellular Location

Virion
Host Golgi apparatus
Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue165Phosphoserine; by host
Modified residue451Phosphothreonine; by host

Post-translational modification

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.

Keywords

Interaction

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues
Region1-64Disordered
Compositional bias21-37Basic and acidic residues
Domain62-186CoV N NTD
Region183-225Disordered
Compositional bias190-215Polar residues
Domain259-376CoV N CTD
Region372-401Disordered
Compositional bias376-394Basic and acidic residues
Region419-468Disordered

Sequence similarities

Belongs to the betacoronavirus nucleocapsid protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    51,457
  • Last updated
    2018-05-23 v1
  • Checksum
    DF62643CBF5CA250
MSGRNRSRSGTPSPKVTFKQESDGSDSESERRNGNRNGARPKNNNSRGNASRPEKPKAAPPQNVSWFAPLVQTGKAELRFPRGEGVPVSQGVDPTYEHGYWLRTQRSFQKGGKQVLANPRWYFYYTGTGRFGDLRFGTKNPDIVWVGQEGANINRPGDMGTRNPSNDGAIQVQLSGGILKGFYAEGRGSRGNSRSGSRSSSGASSRGNSRASSRGASPGRPAANPSAEPWMAYLVQKLEKLESQVNGTKPATKNPVQVTKNEAAANAKKLRHKRTAHKGSGVTVNYGRRGPGDLEGNFGDREMLKLGTDDPRFAAAAQMAPNVSSFLFMSHLSTRDEEDALWLHYKGAIKLPKEDPNYEQWTKILAENLNAYKDFPPTEPKKDKEKKEETAQDTVIFEDASTGTDQPVVKVWVKDQDVQTDDEWLGGGETVYEDEDDRPKTQRRHKKRGSTASRVTIADPTNAGAERS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues
Compositional bias21-37Basic and acidic residues
Compositional bias190-215Polar residues
Compositional bias376-394Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG762667
EMBL· GenBank· DDBJ
AVP25398.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp