A0A2P1ITH4 · A0A2P1ITH4_MERS
- ProteinORF1ab polyprotein
- Geneorf1ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids7077 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- ATP + H2O = ADP + H+ + phosphate
- uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 5997 | |||||
Sequence: D | ||||||
Active site | 5999 | |||||
Sequence: E | ||||||
Active site | 6098 | |||||
Sequence: E | ||||||
Active site | 6175 | |||||
Sequence: H | ||||||
Active site | 6180 | |||||
Sequence: D | ||||||
Binding site | 6238-6244 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DIGNPKG | ||||||
Active site | 6662 | |||||
Sequence: H | ||||||
Active site | 6677 | |||||
Sequence: H | ||||||
Active site | 6717 | |||||
Sequence: K |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameORF1ab polyprotein
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Merbecovirus
Accessions
- Primary accessionA0A2P1ITH4
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2175-2195 | Helical | ||||
Sequence: LRLLLMLCTTMVLLSSVYHLY | ||||||
Transmembrane | 2307-2325 | Helical | ||||
Sequence: WLLLAGTLHYFFAQTSIFV | ||||||
Transmembrane | 2337-2362 | Helical | ||||
Sequence: AFWLFTHIPMAGLVRMYNLLACLWLL | ||||||
Transmembrane | 2755-2776 | Helical | ||||
Sequence: YVLATIIVFLCAVLMYLCLPTF | ||||||
Transmembrane | 3023-3048 | Helical | ||||
Sequence: YFQLTTSLVLGIGLCAFLTLLFYYIN | ||||||
Transmembrane | 3060-3091 | Helical | ||||
Sequence: CAVIAVVAAVLNSLCICFVASIPLCIVPYTAL | ||||||
Transmembrane | 3111-3137 | Helical | ||||
Sequence: WYIMFGPIVPIWMTCVYTVAMCFRHFF | ||||||
Transmembrane | 3563-3581 | Helical | ||||
Sequence: AHWLFATLVSTYVIILQAT | ||||||
Transmembrane | 3593-3612 | Helical | ||||
Sequence: IPTQFFPLLFVTMAFVMLLV | ||||||
Transmembrane | 3619-3637 | Helical | ||||
Sequence: LTLFLLPVAICLTYANIVY | ||||||
Transmembrane | 3668-3686 | Helical | ||||
Sequence: IGVYISMSLVLVIVVKRLY | ||||||
Transmembrane | 3693-3709 | Helical | ||||
Sequence: FALALCSGVMWLYTYSI | ||||||
Transmembrane | 3729-3751 | Helical | ||||
Sequence: YTITVFVTVNLAKVCTYAIFAYS | ||||||
Transmembrane | 3763-3785 | Helical | ||||
Sequence: MILLLYTCLGFMCTCYFGVFSLL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-149 | CoV Nsp1 globular | ||||
Sequence: HQDHVSLTVPLCGSGNLVEKLSPWFMDGENAYEVVKAMLLKKEPLLYVPIRLAGHTRHLPGPRVYLVERLIACENPFMVNQLAYSSSANGSLVGTTLQGKPIGMFFPYDIELVTGKQNILLRKYG | ||||||
Domain | 165-193 | BetaCoV Nsp1 C-terminal | ||||
Sequence: TSCPEWMDDFEADPKGKYAQNLLKKLIGG | ||||||
Domain | 195-475 | CoV Nsp2 N-terminal | ||||
Sequence: VTPVDQYMCGVDGKPISAYAFLMAKDGITKLADVEADVAARADDEGFITLKNNLYRLVWHVERKDVPYPKQSIFTINSVVQKDGVENTPPHYFTLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLENPTYIYHSAFIECGSCGNDSWLTGNAIQGFACGCGASYTANDVEVQSSGMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSERCNVIADSKSFTLIFGGVAYAYFGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQIANM | ||||||
Domain | 481-715 | CoV Nsp2 middle | ||||
Sequence: QHSLNFVGEFVVNDVVLAILSGTTTNVDKIRQLLKGVTLDKLRDYLADYDVAVTAGPFMDNAINVGGTGLQYAAITAPYVVLTGLGESFKKVATIPYKVCYSVKDTLAYYAHSVLYRVFPYDMDSGVSSFSELLFDCVDLSVTSIYFLVRLLQDKTGDFMSTIITSCQTAVSKFLDTCFEATEATFNFLLDLAGLFRIFLRNAYVYTSQGFVVVNGKVSTLVKQVLDLLNKGMQL | ||||||
Domain | 717-853 | CoV Nsp2 C-terminal | ||||
Sequence: HTKVSWAGSKISAVIYSGRESLIFPSGTYYCVTTKAKSVQQDLDVILPGEFSKKQLGLLQPTDNSTTVSVTVSSNMVETVVGQLEQTNMHSPDVIVGDYVIISEKLFVRSKEEDGFAFYPACTNGHAVPTLFRLKGG | ||||||
Domain | 857-966 | Ubiquitin-like | ||||
Sequence: KKVAFGGDQVHEVAAVRSVTVEYNIHAVLDTLLASSSLRTFVVDKSLSIEEFADVVKEQVSDLLVKLLRGMPIPDFDLDDFIDAPCYCFNAEGDASWSSTMIFSLHPVEC | ||||||
Domain | 1110-1276 | Macro | ||||
Sequence: PLSNFEHKVITECVTIVLGDAIQVAKCYGEPVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYRAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIVDI | ||||||
Domain | 1278-1404 | Macro | ||||
Sequence: QSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNNGVDYTKKFLTVDGVQYYCYTSKDTLDDILQQANKSVGIISMPLGYVSHGLDLMQAGSVVRRVNVPYVCLLANKEQEAILMSEDVKLN | ||||||
Domain | 1404-1477 | DPUP | ||||
Sequence: NPSEDFIKHVRTNGGYNSWHLVEGELLVQDLRLNKLLHWSDQTICYKDSVFYVVKNSTAFPFETLSACRAYLDS | ||||||
Domain | 1482-1537 | Ubiquitin-like | ||||
Sequence: QLTIEVLVTVDGVNFRTVVLNNKNTYRSQLGCVFFNGADISDTIPDEKQNGHSLYL | ||||||
Domain | 1552-1823 | Peptidase C16 | ||||
Sequence: LYGPVDPTFLHRFYSLKAAVHRWKMVVCDKVRSFKLSDNNCYLNAVIMTLDLLKDIKFVIPALQHAFMKHKGGDSTDFIALIMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDVVLQGLKACCYVGMQTVEDLRARMTYVCQCGGERHRQLVEHTTPWLLLSGTPNEKLVTTSTAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVTKISDWKCKVTDVLFPGQKYSSDCNVVRYSLDGNFRTEVDPDLSA | ||||||
Domain | 1837-1954 | Nucleic acid-binding | ||||
Sequence: PVTYSPATILAGSVYTNSCLVSSDGQPDGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPTYKNGAMYKGKPILWVNKASYDTNLNKFNXASLRQIFDVAPIEL | ||||||
Domain | 1967-2088 | G2M | ||||
Sequence: PVEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVIFVADDSGTPVVECLSKEDLHTLYVDPKYQVIVLKDNVLSSMLRLHTVESGDINVVAASGSLTRKVKLLFRASFYFKEFATRTFTATIA | ||||||
Domain | 2214-2280 | 3Ecto | ||||
Sequence: KKFYKEVRAYLGISSACDGLASAYRANSFDVPTFCANRSAMCNWCLISQDSITHYPALKMVQTHLSH | ||||||
Region | 2364-2454 | Y1 | ||||
Sequence: KFYQHVINGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDAAGVGNTFICEEVANDLTTALRRPINATD | ||||||
Domain | 2364-2737 | CoV Nsp3 Y | ||||
Sequence: KFYQHVINGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDAAGVGNTFICEEVANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPCYEQFPLCAFTNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHNVLTTFIDAARGPAGVESDVETNEIVDSVQYAHKHDIQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTAKIV | ||||||
Region | 2368-2381 | ZF1 | ||||
Sequence: HVINGCKDTACLLC | ||||||
Region | 2414-2424 | ZF2 | ||||
Sequence: CRRHNWNCVDC | ||||||
Region | 2455-2737 | CoV-Y | ||||
Sequence: RSHYYVDSVTVKETVVQFNYRRDGQPCYEQFPLCAFTNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHNVLTTFIDAARGPAGVESDVETNEIVDSVQYAHKHDIQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTAKIV | ||||||
Region | 2637-2737 | Y4 | ||||
Sequence: IQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTAKIV | ||||||
Domain | 3150-3246 | Nsp4C | ||||
Sequence: VFTDGKLNCSFQDAASNIFVINKDTYAALRNSLTNDAYSRFLGLFNKYKYFSGAMETAAYREAAACHLAKALQTYSETGSDLLYQPPNCSITSGVLQ | ||||||
Domain | 3247-3552 | Peptidase C30 | ||||
Sequence: SGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRVVGHAMQGTLLKLTVDVANPSTPAYTFTTVKPGASFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGYTKEGSVINFCYMHQMELASGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDMLAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQ | ||||||
Domain | 3845-3927 | RdRp Nsp7 cofactor | ||||
Sequence: SKLTDLKCTSVVLLSVLQQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFDTPSVLQ | ||||||
Domain | 3928-4126 | RdRp Nsp8 cofactor | ||||
Sequence: ATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDKAVARKLERMADQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGIISNARNGCIPLSVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDVVDSNENLTWPLVLECTRASTSAVKLQ | ||||||
Domain | 4127-4236 | Nsp9 ssRNA-binding | ||||
Sequence: NNEIKPSGLKTMVVSAGQEQTNCNTSSLAYYEPVQGRKMLMALLSDNAYLKWARVEGKDGFVSVELQPPCKFLIAGPKGPEIRYLYFVKNLNNLHRGQVLGHIAATVRLQ | ||||||
Domain | 4237-4376 | ExoN/MTase coactivator | ||||
Sequence: AGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCVKMLTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPAQCVRDPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQ | ||||||
Domain | 4382-4638 | NiRAN | ||||
Sequence: FLNRVRGSIVNARIEPCSSGLSTDVVFRAFDICNYKAKVAGIGKYYKTNTCRFVELDDQGHHLDSYFVVKRHTMENYELEKHCYDLLRDCDAVAPHDFFIFDVDKVKTPHIVRQRLTEYTMMDLVYALRHFDQNSEVLKAILVKYGCCDVTYFENKLWFDFVENPSVIGVYHKLGERVRQAILNTVKFCDHMVKAGLVGVLTLDNQDLNGKWYDFGDFVITQPGSGVAIVDSYYSYLMPVLSMTDCLAAETHRDCDF | ||||||
Domain | 4643-4741 | Nsp12 Interface | ||||
Sequence: IEWPLTEYDFTDYKVQLFEKYFKYWDQTYHANCVNCTDDRCVLHCANFNVLFAMTMPKTCFGPIVRKIFVDGVPFVVSCGYHYKELGLVMNMDVSLHRH | ||||||
Domain | 4742-5309 | Nsp12 RNA-dependent RNA polymerase | ||||
Sequence: RLSLKELMMYAADPAMHIASSNAFLDLRTSCFSVAALTTGLTFQTVRPGNFNQDFYDFVVSKGFFKEGSSVTLKHFFFAQDGNAAITDYNYYSYNLPTMCDIKQMLFCMEVVNKYFEIYDGGCLNASEVVVNNLDKSAGHPFNKFGKARVYYESMSYQEQDELFAMTKRNVIPTMTQMNLKYAISAKNRARTVAGVSILSTMTNRQYHQKMLKSMAATRGATCVIGTTKFYGGWDFMLKTLYKDVDNPHLMGWDYPKCDRAMPNMCRIFASLILARKHGTCCTTRDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTANVSALMGANGNKIVDKEVKDMQFDLYVNVYRSTSPDPKFVDKYYAFLNKHFSMMILSDDGVVCYNSDYAAKGYIAGIQNFKETLYYQNNVFMSEAKCWVETDLKKGPHEFCSQHTLYIKDGDDGYFLPYPDPSRILSAGCFVDDIVKTDGTLMVERFVSLAIDAYPLTKHEDIEYQNVFWVYLQYIEKLYKDLTGHMLDSYSVMLCGDNSAKFWEEAFYRDLYSSPTTLQ | ||||||
Domain | 4989-5151 | RdRp catalytic | ||||
Sequence: PHLMGWDYPKCDRAMPNMCRIFASLILARKHGTCCTTRDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTANVSALMGANGNKIVDKEVKDMQFDLYVNVYRSTSPDPKFVDKYYAFLNKHFSMMILSDDGVVCYNSDYAAKG | ||||||
Domain | 5310-5393 | CV ZBD | ||||
Sequence: AVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPHKMVLSVSPYVCNAPGCGVSDVTKLYLGGMSYFCVDHRPVCSFPLC | ||||||
Domain | 5566-5922 | +RNA virus helicase C-terminal | ||||
Sequence: TVPEEFASHVANFQKSGYSKYVTVQGPPGTGKSHFAIGLAIYYPTARVVYTACSHAAVDALCEKAFKYLNIAKCSRIIPAKARVECYDRFKVNETNSQYLFSTINALPETSADILVVDEVSMCTNYDLSIINARIKAKHIVYVGDPAQLPAPRTLLTRGTLEPENFNSVTRLMCNLGPDIFLSMCYRCPKEIVSTVSALVYNNKLLAKKELSGQCFKILYKGNVTHDASSAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVARSILGLTTQTVDSSQGSEYQYVIFCQTADTAHANNINRFNVAITRAQKGILCVMTSQALFDSLEFTELSFTNYKLQSQIVTGLFKDCSRET | ||||||
Domain | 5979-6194 | ExoN | ||||
Sequence: LFITREEAVRQVRSWIGFDVEGAHASRNACGTNVPLQLGFSTGVNFVVQPVGVVDTEWGNMLTGIAARPPPGEQFKHLVPLMHKGAAWPIVRRRIVQMLSDTLDKLSDYCTFVCWAHGFELTSASYFCKIGKEQKCCMCNRRAAAYSSPLQSYACWTHSCGYDYVYNPFFVDVQQWGYVGNLATNHDRYCSVHQGAHVASNDAIMTRCLAIHSCFI | ||||||
Domain | 6203-6431 | N7-MTase | ||||
Sequence: YPYISHEKKLNSCCRIVERNVVRAALLAGSFDKVYDIGNPKGIPIVDDPVVDWHYFDAQPLTRKVQQLFYTEDMASSFADGLCLFWNCNVPKYPNNAIVCRFDTRVHSEFNLPGCDGGSLYVNKHAFHTPAYDVSAFRGLKPLPFFYYSTTPCEVHGNGSMIEDIDYVPLKSAVCITACNLGGAVCRKHATEYREYMEAYNLVSASGFRLWCYKTFDIYNLWSTFTKVQ | ||||||
Region | 6317-6331 | GpppA-binding | ||||
Sequence: CDGGSLYVNKHAFHT | ||||||
Domain | 6432-6492 | Nsp15 N-terminal oligomerization | ||||
Sequence: GLENIAFNVVKQGHFIGVEGELPVAVVNDKIFTKSGVNDICMFENKTTLPTNIAFELYAKR | ||||||
Domain | 6493-6615 | AV-Nsp11N/CoV-Nsp15M | ||||
Sequence: AVRSHPDFKFLHNLQADICYKFVLWDYERSNIYGTATIGVCKYTDIDVNSALNICFDIRDNGSLEKFMSTPNAIFISDRKIKKYPCMVGPDYAYFNGAIIRDSDVVKQPVKFYLYKKVNNEFI | ||||||
Domain | 6632-6771 | NendoU | ||||
Sequence: LPLSDMEKDFLSFDSDVFIKKYGLENYAFEHVVYGDFSHTTLGGLHLLIGLYKKQQEGHIIMEEMLKGSSTIHNYFITETNTAAFKAVCSVIDLKLDDFVMILKSQDLGVVSKVVKVPIDLTMIEFMLWCKDGQVQTFYP | ||||||
Domain | 6776-7070 | Nidovirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: SADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQLCQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVLV |
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length7,077
- Mass (Da)789,582
- Last updated2018-05-23 v1
- ChecksumE950ECBA6322B341
Keywords
- Coding sequence diversity