A0A2P1ITH4 · A0A2P1ITH4_MERS

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site5997
Active site5999
Active site6098
Active site6175
Active site6180
Binding site6238-6244S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site6662
Active site6677
Active site6717

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionlyase activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ORF1ab polyprotein

Gene names

    • Name
      orf1ab

Organism names

Accessions

  • Primary accession
    A0A2P1ITH4

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2175-2195Helical
Transmembrane2307-2325Helical
Transmembrane2337-2362Helical
Transmembrane2755-2776Helical
Transmembrane3023-3048Helical
Transmembrane3060-3091Helical
Transmembrane3111-3137Helical
Transmembrane3563-3581Helical
Transmembrane3593-3612Helical
Transmembrane3619-3637Helical
Transmembrane3668-3686Helical
Transmembrane3693-3709Helical
Transmembrane3729-3751Helical
Transmembrane3763-3785Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-149CoV Nsp1 globular
Domain165-193BetaCoV Nsp1 C-terminal
Domain195-475CoV Nsp2 N-terminal
Domain481-715CoV Nsp2 middle
Domain717-853CoV Nsp2 C-terminal
Domain857-966Ubiquitin-like
Domain1110-1276Macro
Domain1278-1404Macro
Domain1404-1477DPUP
Domain1482-1537Ubiquitin-like
Domain1552-1823Peptidase C16
Domain1837-1954Nucleic acid-binding
Domain1967-2088G2M
Domain2214-22803Ecto
Region2364-2454Y1
Domain2364-2737CoV Nsp3 Y
Region2368-2381ZF1
Region2414-2424ZF2
Region2455-2737CoV-Y
Region2637-2737Y4
Domain3150-3246Nsp4C
Domain3247-3552Peptidase C30
Domain3845-3927RdRp Nsp7 cofactor
Domain3928-4126RdRp Nsp8 cofactor
Domain4127-4236Nsp9 ssRNA-binding
Domain4237-4376ExoN/MTase coactivator
Domain4382-4638NiRAN
Domain4643-4741Nsp12 Interface
Domain4742-5309Nsp12 RNA-dependent RNA polymerase
Domain4989-5151RdRp catalytic
Domain5310-5393CV ZBD
Domain5566-5922+RNA virus helicase C-terminal
Domain5979-6194ExoN
Domain6203-6431N7-MTase
Region6317-6331GpppA-binding
Domain6432-6492Nsp15 N-terminal oligomerization
Domain6493-6615AV-Nsp11N/CoV-Nsp15M
Domain6632-6771NendoU
Domain6776-7070Nidovirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    7,077
  • Mass (Da)
    789,582
  • Last updated
    2018-05-23 v1
  • Checksum
    E950ECBA6322B341

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG923480
EMBL· GenBank· DDBJ
AVN89440.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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