A0A2P1IT89 · A0A2P1IT89_MERS
- ProteinORF1a
- Geneorf1a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids4390 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Merbecovirus
Accessions
- Primary accessionA0A2P1IT89
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 2175-2195 | Helical | |||
Transmembrane | 2307-2325 | Helical | |||
Transmembrane | 2337-2362 | Helical | |||
Transmembrane | 2755-2776 | Helical | |||
Transmembrane | 3023-3048 | Helical | |||
Transmembrane | 3060-3091 | Helical | |||
Transmembrane | 3111-3137 | Helical | |||
Transmembrane | 3563-3581 | Helical | |||
Transmembrane | 3593-3612 | Helical | |||
Transmembrane | 3619-3637 | Helical | |||
Transmembrane | 3668-3686 | Helical | |||
Transmembrane | 3692-3710 | Helical | |||
Transmembrane | 3731-3751 | Helical | |||
Transmembrane | 3763-3785 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 25-149 | CoV Nsp1 globular | |||
Domain | 165-193 | BetaCoV Nsp1 C-terminal | |||
Domain | 195-475 | CoV Nsp2 N-terminal | |||
Domain | 481-715 | CoV Nsp2 middle | |||
Domain | 717-853 | CoV Nsp2 C-terminal | |||
Domain | 857-966 | Ubiquitin-like | |||
Domain | 1110-1276 | Macro | |||
Domain | 1278-1404 | Macro | |||
Domain | 1404-1477 | DPUP | |||
Domain | 1482-1537 | Ubiquitin-like | |||
Domain | 1552-1823 | Peptidase C16 | |||
Domain | 1837-1954 | Nucleic acid-binding | |||
Domain | 1967-2088 | G2M | |||
Domain | 2214-2280 | 3Ecto | |||
Region | 2364-2454 | Y1 | |||
Domain | 2364-2737 | CoV Nsp3 Y | |||
Region | 2368-2381 | ZF1 | |||
Region | 2414-2424 | ZF2 | |||
Region | 2455-2737 | CoV-Y | |||
Region | 2637-2737 | Y4 | |||
Domain | 3150-3246 | Nsp4C | |||
Domain | 3247-3552 | Peptidase C30 | |||
Domain | 3845-3927 | RdRp Nsp7 cofactor | |||
Domain | 3928-4126 | RdRp Nsp8 cofactor | |||
Domain | 4127-4236 | Nsp9 ssRNA-binding | |||
Domain | 4237-4376 | ExoN/MTase coactivator | |||
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain