A0A2P1IT89 · A0A2P1IT89_MERS

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionmethyltransferase activity
Molecular Functionomega peptidase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological Processinduction by virus of host autophagy
Biological Processmethylation
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral genome replication
Biological Processviral protein processing
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ORF1a

Gene names

    • Name
      orf1a

Organism names

Accessions

  • Primary accession
    A0A2P1IT89

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2175-2195Helical
Transmembrane2307-2325Helical
Transmembrane2337-2362Helical
Transmembrane2755-2776Helical
Transmembrane3023-3048Helical
Transmembrane3060-3091Helical
Transmembrane3111-3137Helical
Transmembrane3563-3581Helical
Transmembrane3593-3612Helical
Transmembrane3619-3637Helical
Transmembrane3668-3686Helical
Transmembrane3692-3710Helical
Transmembrane3731-3751Helical
Transmembrane3763-3785Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain25-149CoV Nsp1 globular
Domain165-193BetaCoV Nsp1 C-terminal
Domain195-475CoV Nsp2 N-terminal
Domain481-715CoV Nsp2 middle
Domain717-853CoV Nsp2 C-terminal
Domain857-966Ubiquitin-like
Domain1110-1276Macro
Domain1278-1404Macro
Domain1404-1477DPUP
Domain1482-1537Ubiquitin-like
Domain1552-1823Peptidase C16
Domain1837-1954Nucleic acid-binding
Domain1967-2088G2M
Domain2214-22803Ecto
Region2364-2454Y1
Domain2364-2737CoV Nsp3 Y
Region2368-2381ZF1
Region2414-2424ZF2
Region2455-2737CoV-Y
Region2637-2737Y4
Domain3150-3246Nsp4C
Domain3247-3552Peptidase C30
Domain3845-3927RdRp Nsp7 cofactor
Domain3928-4126RdRp Nsp8 cofactor
Domain4127-4236Nsp9 ssRNA-binding
Domain4237-4376ExoN/MTase coactivator

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,390
  • Mass (Da)
    486,226
  • Last updated
    2018-05-23 v1
  • Checksum
    1BF56B5FA30B249E

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG923474
EMBL· GenBank· DDBJ
AVN89375.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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