A0A2P1IT77 · A0A2P1IT77_MERS
- ProteinORF1ab polyprotein
- Geneorf1ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids7078 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- ATP + H2O = ADP + H+ + phosphate
- uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 5998 | |||||
Sequence: D | ||||||
Active site | 6000 | |||||
Sequence: E | ||||||
Active site | 6099 | |||||
Sequence: E | ||||||
Active site | 6176 | |||||
Sequence: H | ||||||
Active site | 6181 | |||||
Sequence: D | ||||||
Binding site | 6239-6245 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DIGNPKG | ||||||
Active site | 6663 | |||||
Sequence: H | ||||||
Active site | 6678 | |||||
Sequence: H | ||||||
Active site | 6718 | |||||
Sequence: K |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameORF1ab polyprotein
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Merbecovirus
Accessions
- Primary accessionA0A2P1IT77
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2175-2195 | Helical | ||||
Sequence: LRLLLMLCTTMVLLSSVYHLY | ||||||
Transmembrane | 2307-2325 | Helical | ||||
Sequence: WLLLAGTLHYFFAQTSIFV | ||||||
Transmembrane | 2337-2362 | Helical | ||||
Sequence: AFWLFTHIPMAGLVRMYNLLACLWLL | ||||||
Transmembrane | 2756-2777 | Helical | ||||
Sequence: YVLATIIVFLCAVLMYLCLPTF | ||||||
Transmembrane | 3024-3049 | Helical | ||||
Sequence: YFQLTTSLVLGIGLCAFLTLLFYYIN | ||||||
Transmembrane | 3061-3092 | Helical | ||||
Sequence: CAVIAVVAAVLNSLCICFVASIPLCIVPYTAL | ||||||
Transmembrane | 3112-3138 | Helical | ||||
Sequence: WYIMFGPIVPIWMTCVYTVAMCFRHFF | ||||||
Transmembrane | 3564-3582 | Helical | ||||
Sequence: AHWLFATLVSTYVIILQAT | ||||||
Transmembrane | 3594-3613 | Helical | ||||
Sequence: IPTQLFPLLFVTMAFVMLLV | ||||||
Transmembrane | 3620-3638 | Helical | ||||
Sequence: LTLFLLPVAICLTYANIVY | ||||||
Transmembrane | 3669-3687 | Helical | ||||
Sequence: IGVYISMSLVLVIVVKRLY | ||||||
Transmembrane | 3694-3710 | Helical | ||||
Sequence: FALALCSGVMWLYTYSI | ||||||
Transmembrane | 3730-3752 | Helical | ||||
Sequence: YTITVFVTVNLAKVCTYAIFAYS | ||||||
Transmembrane | 3764-3786 | Helical | ||||
Sequence: MILLLYTCLGFMCTCYFGVFSLL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-149 | CoV Nsp1 globular | ||||
Sequence: HQDHVSLTVPLCGSGNLVEKLSPWFMDGENAYEVVKAMLLKKEPLLYVPIRLAGHTRHLPGPRVYLVERLIACENPFMVNQLAYSSSANGSLVCTTLQGKPIGMFFPYDIELVTGKQNILLRKYG | ||||||
Domain | 165-193 | BetaCoV Nsp1 C-terminal | ||||
Sequence: TSCPEWMDDFEADPKGKYAQNLLKKLIGG | ||||||
Domain | 195-475 | CoV Nsp2 N-terminal | ||||
Sequence: VTPVDQYMCGVDGKPISAYAFLMAKDGITKLADVEADVAARADDEGFITLKNNLYRLVWHVERKDVPYPKQSIFTINSVVQKDGVENTPPHYFTLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLENPTYIYHSAFIECGSCGNESWLTGNAIQGFACGCGASYTANDVEVQSSGMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSERCNVIADSKSFTLIFGGVAYAYFGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQIANM | ||||||
Domain | 481-715 | CoV Nsp2 middle | ||||
Sequence: QHSLNFVGEFVVNDVVIAILSGTTTNVEKIRQLLKGVTLDKLRDYLADYDVAVTAGPFMDDAINVGGTGLQYAAITAPYVVLTGLGESFKKVATIPYKVCYSVKDTLAYYAHSVLYRVFPYDMDSGVSSFSELLFDCVDLSVASTYFLVRLLQDKTGDFMSTIITSCQTAVSKFLDTCFEATEATFNFLLDLAGLFRIFLRNAYVYTSQGFVVVNGKVSTLVKQVLDLLNKGMQL | ||||||
Domain | 717-853 | CoV Nsp2 C-terminal | ||||
Sequence: HTKVSWAGSKISAVIYSGRESLIFPSGTYYCVTTKAKSVQQDLDVILPGEFSKKQLGLLQPTDNSTTVSVTVSSNMVETVVGQLEQTNMHSPDVIVGDYVIISEKLFVRSKEEDGFAFYPACTNGHAVPTLFRLKGG | ||||||
Domain | 857-966 | Ubiquitin-like | ||||
Sequence: KKVAFGGDQVHEVAAVRSVTVEYNIHAVLDTLLASSSLRTFVVDKSLSIEEFADVVKEQVSDLLVKLLRGMPIPDFDLDDFIDAPCYCFNAEGDAFWSSTMIFSLHPVEC | ||||||
Domain | 1110-1276 | Macro | ||||
Sequence: PLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIVDI | ||||||
Domain | 1278-1404 | Macro | ||||
Sequence: QSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNKGVDYTKKFLTVDGVQYYCYTSKDTLDDILQQANKSVGIISMPLGYVSHGLDLMQAGSVVRRVNVPYVCLLANKEQEAILMSEDVKLN | ||||||
Domain | 1404-1477 | DPUP | ||||
Sequence: NPSEDFIKHVRTNGGYNSWHLVEGELLVQDLRLNKLLHWSDQTICYKDSVFYVVKNSTAFPFETLSACRAYLDS | ||||||
Domain | 1482-1537 | Ubiquitin-like | ||||
Sequence: QLTIEVLVTVDGVNFRTVVLNNKNTYISQLGCVFFNGADISDTIPDEKQNGHSLYL | ||||||
Domain | 1552-1823 | Peptidase C16 | ||||
Sequence: LYGPVDPTFLHRFYSLKAAVHRWKMVVCDKVRFFKLSDNNCYLNAVIMTLDLLKDIKFVIPALQHAFMKHKGGDSTDFIALIMAYGNCTFGDPDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDVVLQGLKACCYVGVQTVEDLRARMTYVCQCGGERHQQLVEHTTPWLLLSGTPNEKLVTTSTAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTSDWKCKVTDVLFPGQKYSSDCNVVRYSLDGNFRTEVDPDLSA | ||||||
Domain | 1837-1954 | Nucleic acid-binding | ||||
Sequence: PVTYSPATILAGSVYTNSCLVSSDGQPGGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPTYKNGAMYKGKPILWVNKASYDTNLNKFNGASLRQIFDVAPIEL | ||||||
Domain | 1967-2088 | G2M | ||||
Sequence: PVEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVIFVADDSGTPVVEYLSKEDLHTLYVDPKYQVIVLKDNVLSSMLRLHTVESGDINVVAASGSLTRKVKLLFRASFYFKEFATRTFTATTA | ||||||
Domain | 2214-2280 | 3Ecto | ||||
Sequence: KKFYKEVRAYLGISSACDGLASAYRANSFDVPTFCANRSAMCNWCLISQDSITHYPALKMVQTHLSH | ||||||
Region | 2364-2454 | Y1 | ||||
Sequence: KFYQHVINGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCHRHNWNCVDCDAAGVGNTFICEEVANDLTTALRRPINATD | ||||||
Domain | 2364-2737 | CoV Nsp3 Y | ||||
Sequence: KFYQHVINGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCHRHNWNCVDCDAAGVGNTFICEEVANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPCYERFPLCAFTNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAARGPAGVESDVETNEIVDSVQYAHKHDIQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTANKI | ||||||
Region | 2368-2381 | ZF1 | ||||
Sequence: HVINGCKDTACLLC | ||||||
Region | 2414-2424 | ZF2 | ||||
Sequence: CHRHNWNCVDC | ||||||
Region | 2455-2737 | CoV-Y | ||||
Sequence: RSHYYVDSVTVKETVVQFNYRRDGQPCYERFPLCAFTNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAARGPAGVESDVETNEIVDSVQYAHKHDIQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTANKI | ||||||
Region | 2637-2737 | Y4 | ||||
Sequence: IQLTNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQTVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTANKI | ||||||
Domain | 3151-3247 | Nsp4C | ||||
Sequence: VFTDGRLNCSFQDAASNIFVINKDTYAALRNSLTNDAYSRFLGLFNKYKYFSGAMETAAYREAAACHLAKALQTYSETGSDLLYQPPNCSITSGVLQ | ||||||
Domain | 3248-3553 | Peptidase C30 | ||||
Sequence: SGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRVVGHAMQGTLLKLTVDVANPSTPAYTFTTVKPGASFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDMLAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQ | ||||||
Domain | 3846-3928 | RdRp Nsp7 cofactor | ||||
Sequence: SKLTDLKCISVVLLSVLQQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFDTPSVLQ | ||||||
Domain | 3929-4127 | RdRp Nsp8 cofactor | ||||
Sequence: ATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDKAVARKLERMADQAMTSMYKQARAEDKKAKIISAMQTMLFGMIKKLDNDVLNGIISNARNGCIPLSVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDVVDSNENLTWPLVLECTRASTSAVKLQ | ||||||
Domain | 4128-4237 | Nsp9 ssRNA-binding | ||||
Sequence: NNEIKPSGLKTMVVSAGQEQTNCNTSSLAYYEPVQGRKMLMALLSDNAYLKWARVEGKDGFVSVELQPPCKFLIAGPKGPEIRYLYFVKNLNNLHRGQVLGHIAATVRLQ | ||||||
Domain | 4238-4377 | ExoN/MTase coactivator | ||||
Sequence: AGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCVKMLTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPAQCVRDPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQ | ||||||
Domain | 4383-4639 | NiRAN | ||||
Sequence: FLNRVRGSIVNARIEPCSSGLSTDVVFRAFDICNYKAKVAGIGKYYKTNTCRFVELDDQGHHLDSYFVVKRHTMENYELEKHCYDLLRDCDAVAPHDFFIFDVDKVKTPHIVRQRLTEYTMMDLVYALRHFDQNSEVLKAILVKYGCCDVTYFENKLWFDFVENPSVIGVYHKLGERVRQAILNTVKFCDHIVKAGLVGVLTLDNQDLNGKWYDFGDFVITQPGSGVAIVDSYYSYLMPVLSMTDCLAAETHRDCDF | ||||||
Domain | 4644-4742 | Nsp12 Interface | ||||
Sequence: IEWPLTEYDFTDYKVQLFEKYFKYWDQTYHANCVNCTDDRCVLHCANFNVLFAMTMPKTCFGPIVRKIFVDGVPFVVSCGYHYKELGLVMNMDVSVHRH | ||||||
Domain | 4743-5310 | Nsp12 RNA-dependent RNA polymerase | ||||
Sequence: RLSLKELMMYAADPAMHIASSNAFLDLRTSCFSVAALTTGLTFQTVRPGNFNQDFYDFVVSKGFFKEGSSVTLKHFFFAQDGNAAITDYNYYSYNLPTMCDIKQMLFCMEVVNKYFEIYDGGCLNASEVVVNNLDKSAGHPFNKFGKARVYYESMSYQEQDELFAMTKRNVIPTMTQMNLKYAISAKNRARTVAGVSILSTMTNRQYHQKMLKSMAATRGATCVIGTTKFYGGWDFMLKTLYKDVDNPHLMGWDYPKCDRAMPNMCRIFASLILARKHGTCCTTRDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTANVSALMGANGNKIVDKEVKDMQFDLYVNVYRSTSPDPKFVDKYYAFLNKHFSMMILSDDGVVCYNSDYAAKGYIAGIQNFKETLYYQNNVFMSEAKCWLETDLKKGPHEFCSQHTLYIKDGDDGYFLPYPDPSRILSAGCFVDDIVKTDGTLMVERFVSLAIDAYPLTKHEDIEYQNVFWVYLQYIEKLYKDLTGHMLDSYSVMLCGDNSAKFWEEAFYRDLYSSPTTLQ | ||||||
Domain | 4990-5152 | RdRp catalytic | ||||
Sequence: PHLMGWDYPKCDRAMPNMCRIFASLILARKHGTCCTTRDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTANVSALMGANGNKIVDKEVKDMQFDLYVNVYRSTSPDPKFVDKYYAFLNKHFSMMILSDDGVVCYNSDYAAKG | ||||||
Domain | 5311-5394 | CV ZBD | ||||
Sequence: AVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPHKMVLSVSPYVCNAPGCGVSDVTKLYLGGMSYFCVDHRPVCSFPLC | ||||||
Domain | 5567-5923 | +RNA virus helicase C-terminal | ||||
Sequence: TVPEEFASHVANFQKSGYSKYVTVQGPPGTGKSHFAIGLAIYYPTARVVYTACSHAAVDALCEKAFKYLNIAKCSRIIPAKARVECYDRFKVNETNSQYLFSTINALPETSADILVVDEVSMCTNYDLSIINARIKAKHIVYVGDPAQLPAPRTLLTRGTLEPENFNSVTRLMCNLGPDIFLSMCYRCPKEIVSTVSALVYNNKLLAKKEFSGQCFKILYKGNVTHDASSAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVARSMLGLTTQTVDSSQGSEYQYVIFCQTADTAHANNINRFNVAITRAQKGILCVMTSQALFDSLEFTELSFTNYKLQSQIVTGLFKDCSRET | ||||||
Domain | 5980-6195 | ExoN | ||||
Sequence: LFITREEAVRQVRSWIGFDVEGAHASRNACGTNVPLQLGFSTGVNFVVQPVGVVDTEWGNMLTGIAARPPPGEQFKHLVPLMHKGAAWPIVRRRIVQMLSDTLDKLSDYCTFVCWAHGFELTSASYFCKIGKEQKCCMCNRRAAAYSSPLQSYACWTHSCGYDYVYNPFFVDVQQWGYVGNLATNHDRYCSVHQGAHVASNDAIMTRCLAIHSCFI | ||||||
Domain | 6204-6432 | N7-MTase | ||||
Sequence: YPYISHEKKLNSCCRIVERNVVRAALLAGSFDKVYDIGNPKGIPIFDDPVVDWHYFDAQPLTRKVQQLFYTEDMASRFADGLCLFWNCNVPKYPNNAIVCRFDTRVHSEFNLPGCDGGSLYVNKHAFHTPAYDVSAFRDLKPLPFFYYSTTPCEVHGNGSMIEDIDYVPLKSAVCITACNLGGAVCRKHATEYREYMEAYNLVSASGFRLWCYKTFDIYNLWSTFTKVQ | ||||||
Region | 6318-6332 | GpppA-binding | ||||
Sequence: CDGGSLYVNKHAFHT | ||||||
Domain | 6433-6493 | Nsp15 N-terminal oligomerization | ||||
Sequence: GLENIAFNVVKQGHFIGVEGELPVAVVNDKIFTKSGVNDICMFENKTTLPTNIAFELYAKR | ||||||
Domain | 6494-6616 | AV-Nsp11N/CoV-Nsp15M | ||||
Sequence: AVRSHPDFKFLHNLQADICYKFVLWDYERSNIYGTATIGVCKYTDIDVNSALNICFDIRDNGSLEKFMSTPNAIFISDRKIKKYPCMVGPDYAYFNGAIIRDSDVVKQPVKFYLYKKVNNEFI | ||||||
Domain | 6633-6772 | NendoU | ||||
Sequence: LPLSDMEKDFLSFDSDVFIKKYGLENYAFEHVVYGDFSHTTLGGLHLLIGLYKKQQEGHIIMEEMLKGSSTIHNYFITETNTAAFKAVCSVIDLKLDDFVMILKSQDLGVVSKVVKVPIDLTMIEFMLWCKDGQVQTFYP | ||||||
Domain | 6777-7071 | Nidovirus-type SAM-dependent 2'-O-MTase | ||||
Sequence: SADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQLCQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTSVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVLV |
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length7,078
- Mass (Da)789,909
- Last updated2018-05-23 v1
- ChecksumF3262279F871D4B9
Keywords
- Coding sequence diversity