A0A2P1H683 · A0A2P1H683_HUMAN
- ProteinZinc finger homeobox protein 2
- GeneZFHX2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2572 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 1595-1654 | Homeobox | ||||
Sequence: RRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNA | ||||||
DNA binding | 1857-1916 | Homeobox | ||||
Sequence: DKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQ | ||||||
DNA binding | 2065-2124 | Homeobox | ||||
Sequence: QRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | zinc ion binding | |
Biological Process | adult behavior | |
Biological Process | regulation of sensory perception of pain |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A2P1H683
Organism-specific databases
Subcellular Location
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-57 | Polar residues | ||||
Sequence: MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPG | ||||||
Region | 1-107 | Disordered | ||||
Sequence: MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPP | ||||||
Region | 343-425 | Disordered | ||||
Sequence: LSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDY | ||||||
Domain | 453-481 | C2H2-type | ||||
Sequence: LKCPKCNWHYKYQQTLDVHMREKHPESNS | ||||||
Region | 537-566 | Disordered | ||||
Sequence: QGFQAGPGGQGSPPEASLPPSAGDKEPKTK | ||||||
Region | 608-655 | Disordered | ||||
Sequence: LPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPD | ||||||
Compositional bias | 610-627 | Pro residues | ||||
Sequence: PGLMGPGPPPPPGATPTS | ||||||
Region | 675-710 | Disordered | ||||
Sequence: RKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPP | ||||||
Compositional bias | 693-710 | Polar residues | ||||
Sequence: PSQLLGSSSDSLPTSPPP | ||||||
Region | 929-974 | Disordered | ||||
Sequence: QLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSA | ||||||
Compositional bias | 954-968 | Basic and acidic residues | ||||
Sequence: KTEQLASEETENKTG | ||||||
Region | 1061-1171 | Disordered | ||||
Sequence: PTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTMAEEEEGTTGELRSAEPAPADSRHPL | ||||||
Compositional bias | 1095-1109 | Pro residues | ||||
Sequence: EASPDPLPEPPLASV | ||||||
Compositional bias | 1116-1138 | Pro residues | ||||
Sequence: SGSPGQPPSPAPSPVPEPDAQAE | ||||||
Domain | 1191-1222 | C2H2-type | ||||
Sequence: YKCTVCKESFTQKNILLVHYNSVSHLHKMKKA | ||||||
Domain | 1248-1277 | C2H2-type | ||||
Sequence: FKCTVCRVSYNQSSTLEIHMRSVLHQTRSR | ||||||
Region | 1269-1325 | Disordered | ||||
Sequence: SVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGLPFLSP | ||||||
Compositional bias | 1275-1308 | Basic and acidic residues | ||||
Sequence: RSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEK | ||||||
Compositional bias | 1389-1403 | Pro residues | ||||
Sequence: LPAATPPPPPQPPKA | ||||||
Region | 1389-1408 | Disordered | ||||
Sequence: LPAATPPPPPQPPKAELAER | ||||||
Region | 1415-1434 | Disordered | ||||
Sequence: MAKEGNEAGPSSPPDPLPNE | ||||||
Domain | 1480-1508 | C2H2-type | ||||
Sequence: LACGACGKLFSNMLILKTHEEHVHRRFLP | ||||||
Region | 1528-1591 | Disordered | ||||
Sequence: PPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLV | ||||||
Compositional bias | 1529-1553 | Pro residues | ||||
Sequence: PLAEPPKPPDGSLDSPVPHLGPPFL | ||||||
Compositional bias | 1561-1581 | Basic and acidic residues | ||||
Sequence: GTRAPEERSRAGGHWPIEEEE | ||||||
Domain | 1593-1653 | Homeobox | ||||
Sequence: AGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKN | ||||||
Region | 1696-1769 | Disordered | ||||
Sequence: QTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAH | ||||||
Compositional bias | 1697-1725 | Acidic residues | ||||
Sequence: TLEEEEEEAERGEEEEEVEEEEVEEEQGL | ||||||
Domain | 1769-1791 | C2H2-type | ||||
Sequence: HTCDQCAISFSSQDLLTSHRRLH | ||||||
Region | 1820-1860 | Disordered | ||||
Sequence: AATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRL | ||||||
Domain | 1855-1915 | Homeobox | ||||
Sequence: PRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKG | ||||||
Region | 1912-2065 | Disordered | ||||
Sequence: ERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQ | ||||||
Compositional bias | 1983-2007 | Pro residues | ||||
Sequence: PGKEATTPTPEPPLPLLPPPPPSEE | ||||||
Compositional bias | 2024-2040 | Polar residues | ||||
Sequence: SLSAGDLSDSSASSLAE | ||||||
Domain | 2063-2123 | Homeobox | ||||
Sequence: MGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKA | ||||||
Region | 2268-2327 | Disordered | ||||
Sequence: VQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDAL | ||||||
Compositional bias | 2281-2296 | Polar residues | ||||
Sequence: PMPDQTNTSTAGTTDP | ||||||
Region | 2398-2431 | Disordered | ||||
Sequence: NALLQPPPQPPEPTATAPPKPPELPAPGEGEAGE | ||||||
Compositional bias | 2400-2423 | Pro residues | ||||
Sequence: LLQPPPQPPEPTATAPPKPPELPA | ||||||
Region | 2551-2572 | Disordered | ||||
Sequence: EARLPHTDSNPKTTTTSTLLAL | ||||||
Compositional bias | 2558-2572 | Polar residues | ||||
Sequence: DSNPKTTTTSTLLAL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,572
- Mass (Da)274,176
- Last updated2018-05-23 v1
- Checksum239C8050F65B25C2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-57 | Polar residues | ||||
Sequence: MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPG | ||||||
Compositional bias | 610-627 | Pro residues | ||||
Sequence: PGLMGPGPPPPPGATPTS | ||||||
Compositional bias | 693-710 | Polar residues | ||||
Sequence: PSQLLGSSSDSLPTSPPP | ||||||
Compositional bias | 954-968 | Basic and acidic residues | ||||
Sequence: KTEQLASEETENKTG | ||||||
Compositional bias | 1095-1109 | Pro residues | ||||
Sequence: EASPDPLPEPPLASV | ||||||
Compositional bias | 1116-1138 | Pro residues | ||||
Sequence: SGSPGQPPSPAPSPVPEPDAQAE | ||||||
Compositional bias | 1275-1308 | Basic and acidic residues | ||||
Sequence: RSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEK | ||||||
Compositional bias | 1389-1403 | Pro residues | ||||
Sequence: LPAATPPPPPQPPKA | ||||||
Compositional bias | 1529-1553 | Pro residues | ||||
Sequence: PLAEPPKPPDGSLDSPVPHLGPPFL | ||||||
Compositional bias | 1561-1581 | Basic and acidic residues | ||||
Sequence: GTRAPEERSRAGGHWPIEEEE | ||||||
Compositional bias | 1697-1725 | Acidic residues | ||||
Sequence: TLEEEEEEAERGEEEEEVEEEEVEEEQGL | ||||||
Compositional bias | 1983-2007 | Pro residues | ||||
Sequence: PGKEATTPTPEPPLPLLPPPPPSEE | ||||||
Compositional bias | 2024-2040 | Polar residues | ||||
Sequence: SLSAGDLSDSSASSLAE | ||||||
Compositional bias | 2281-2296 | Polar residues | ||||
Sequence: PMPDQTNTSTAGTTDP | ||||||
Compositional bias | 2400-2423 | Pro residues | ||||
Sequence: LLQPPPQPPEPTATAPPKPPELPA | ||||||
Compositional bias | 2558-2572 | Polar residues | ||||
Sequence: DSNPKTTTTSTLLAL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY781180 EMBL· GenBank· DDBJ | AVN67042.1 EMBL· GenBank· DDBJ | mRNA |