A0A2P1DP89 · MACR_PENTR
- ProteinTranscription factor macR
- GenemacR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids853 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of macrophorins, isoprenoid epoxycyclohexenones containing cyclized drimane moieties.
Miscellaneous
The macrophorins cluster contains a single gene insertion (encoding for the terpene cyclase macJ) compared with the yanuthone cluster that produces the linear compound yanuthone.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 18-45 | Zn2-C6 fungal-type | ||||
Sequence: CIVCRRRKVRCGREQPECANCVRMKENC |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription factor macR
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium
Accessions
- Primary accessionA0A2P1DP89
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454093 | 1-853 | Transcription factor macR | |||
Sequence: MPLSEPRQIKKPRLSLSCIVCRRRKVRCGREQPECANCVRMKENCVYRTMVRDESTGRVRPVSPQDKDSRVSTSDARPDLPWPHWGRDTNAPYPDKPSRPPSRPQVSANASPSPQRQEPYPTVPSWEEAIQLPSYRDANAPQINGSSTTTRDPSPAPSTSLFPTPSDHPCRDYLSIRRGGRVRYVGQTFWGFVAGKESLSDDFFDENRHAHPDLPLPHISSMGMFNLLRSLPTKPVSDTLLETFFLAVWPLVPLLHPPSLQADYDEFWEWCRNSENALPSDKLRDDPTLICLLFAVLYCGASAAPAATWANTNLQGLQKETTVSHLKSAYTTSLSLCQHQEHPTLNTLVSNLLTGPFLDRPFEPMRSLVNVSTTVRIAQTMGLHREGAWSALSSVDREIRRRVWWHIVWLDVQSSISTGLTPCCGNEALDAVGMVGTDHVEPSNIPAGLSPPNELVTNRQSVAMLYAIGRFQTARLQARIVAHLQSAHDPSQDGFGELITDSKELLQKIDSLIARVPTQGIPEMGYIPSRLANASPSTQPLLYKDDPSQPTVFSAWTRIMLTLLKSEMAILLQKPFLPPPDSANPQSLKSWTSMAQLCVNYLRIYLQLYQAPAFSPYAWFCCSHYGPLQCVFITLMYLHYFQHSGETTLARYCVDEVIHHCVAQYQAPDPSSTRTSPDDTDSNGGKLRMPLAIQVLVDLHERLDSSLGPEDRAPPLDLIECQARFSMSHLATKASDLRATSDQPSSDVSSTTRTHHNCETPPITTGAPPVAAGNKPVPPNSVFVAGSDSGLDMDFLATISDLEAWSSSLILESDNLLARPDDMTPDHAVITRLGSQSTASGRRGLPDGLDFPG |
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 54-74 | Basic and acidic residues | ||||
Sequence: ESTGRVRPVSPQDKDSRVSTS | ||||||
Region | 54-122 | Disordered | ||||
Sequence: ESTGRVRPVSPQDKDSRVSTSDARPDLPWPHWGRDTNAPYPDKPSRPPSRPQVSANASPSPQRQEPYPT | ||||||
Compositional bias | 102-116 | Polar residues | ||||
Sequence: SRPQVSANASPSPQR | ||||||
Compositional bias | 138-165 | Polar residues | ||||
Sequence: ANAPQINGSSTTTRDPSPAPSTSLFPTP | ||||||
Region | 138-166 | Disordered | ||||
Sequence: ANAPQINGSSTTTRDPSPAPSTSLFPTPS | ||||||
Compositional bias | 734-761 | Polar residues | ||||
Sequence: ASDLRATSDQPSSDVSSTTRTHHNCETP | ||||||
Region | 734-775 | Disordered | ||||
Sequence: ASDLRATSDQPSSDVSSTTRTHHNCETPPITTGAPPVAAGNK | ||||||
Region | 833-853 | Disordered | ||||
Sequence: LGSQSTASGRRGLPDGLDFPG |
Family and domain databases
Sequence
- Sequence statusComplete
- Length853
- Mass (Da)94,426
- Last updated2018-05-23 v1
- ChecksumCD64932694D4F64D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 54-74 | Basic and acidic residues | ||||
Sequence: ESTGRVRPVSPQDKDSRVSTS | ||||||
Compositional bias | 102-116 | Polar residues | ||||
Sequence: SRPQVSANASPSPQR | ||||||
Compositional bias | 138-165 | Polar residues | ||||
Sequence: ANAPQINGSSTTTRDPSPAPSTSLFPTP | ||||||
Compositional bias | 734-761 | Polar residues | ||||
Sequence: ASDLRATSDQPSSDVSSTTRTHHNCETP |