A0A2N7Y6M7 · A0A2N7Y6M7_9PSED
- ProteinUracil phosphoribosyltransferase
- Geneupp
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids212 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Catalytic activity
- UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
Cofactor
Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.
Activity regulation
Allosterically activated by GTP.
Pathway
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 78 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 103 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 130-138 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 193 | uracil (UniProtKB | ChEBI) | |||
Binding site | 198-200 | uracil (UniProtKB | ChEBI) | |||
Binding site | 199 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | uracil phosphoribosyltransferase activity | |
Biological Process | UMP salvage | |
Biological Process | uracil salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUracil phosphoribosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A2N7Y6M7
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length212
- Mass (Da)22,996
- Last updated2018-04-25 v1
- MD5 Checksum25259876FC31071CF77AF1CE25A71B5A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PODW01000017 EMBL· GenBank· DDBJ | PMV12141.1 EMBL· GenBank· DDBJ | Genomic DNA |