A0A2N7UZ02 · A0A2N7UZ02_XANCJ
- ProteinCytochrome c oxidase subunit 1
- GenectaD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids534 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionA0A2N7UZ02
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 32-53 | Helical | ||||
Sequence: LYLLFSFVMFIIGAAMSVVIRA | ||||||
Transmembrane | 73-94 | Helical | ||||
Sequence: TVHALVMIFGGVMPAFVGLANW | ||||||
Transmembrane | 115-135 | Helical | ||||
Sequence: FWLLPVAFTLLLLTLFLPGGA | ||||||
Transmembrane | 155-182 | Helical | ||||
Sequence: AFSVFAIHVAGVSSIMGAINIIATVLNM | ||||||
Transmembrane | 194-221 | Helical | ||||
Sequence: IFCWAWLITAFLLIAVMPVLAGAVTMLL | ||||||
Transmembrane | 241-265 | Helical | ||||
Sequence: MYQHIFWFFGHPEVYIMILPAFGVV | ||||||
Transmembrane | 277-301 | Helical | ||||
Sequence: LFGYQAMVYAIAAIAFLSFIVWAHH | ||||||
Transmembrane | 313-335 | Helical | ||||
Sequence: IYFMFATMLISIPTGVKVFNWVS | ||||||
Transmembrane | 347-371 | Helical | ||||
Sequence: PMLWAVAFVILFSIGGFSGLMLAIV | ||||||
Transmembrane | 383-407 | Helical | ||||
Sequence: VVAHFHYVLVTGAVFALIAAVYYWW | ||||||
Transmembrane | 419-440 | Helical | ||||
Sequence: WAKFHFWWTMVFVNLLFFPQHF | ||||||
Transmembrane | 460-486 | Helical | ||||
Sequence: WNLISSIGAFGMFATPFLMAGILLASL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-523 | Cytochrome oxidase subunit I profile | ||||
Sequence: WFFSTNHKDIGTLYLLFSFVMFIIGAAMSVVIRAELMQPGLQFVKPEFFNQMTTVHALVMIFGGVMPAFVGLANWMIPLQIGAPDMALPRMNNWSFWLLPVAFTLLLLTLFLPGGAPAGGWTLYPPLSLQGGYNVAFSVFAIHVAGVSSIMGAINIIATVLNMRAPGIDLLKMPIFCWAWLITAFLLIAVMPVLAGAVTMLLTDKFFGTSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGVVSEIIPTFSRKPLFGYQAMVYAIAAIAFLSFIVWAHHMFTVGMPLGGEIYFMFATMLISIPTGVKVFNWVSTMWKGSLTFESPMLWAVAFVILFSIGGFSGLMLAIVPADFQYHDTYFVVAHFHYVLVTGAVFALIAAVYYWWPKWTGRMYNETWAKFHFWWTMVFVNLLFFPQHFLGLAGMPRRIPDYNVVFADWNLISSIGAFGMFATPFLMAGILLASLRSGAKADARAWEGAKGLEWTVPSPAPAHTFTVPPVIK |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length534
- Mass (Da)59,365
- Last updated2018-04-25 v1
- Checksum5168CB82E3DE12A7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LR824643 EMBL· GenBank· DDBJ | CAD0311755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR861807 EMBL· GenBank· DDBJ | CAD1786777.1 EMBL· GenBank· DDBJ | Genomic DNA |