A0A2N7BH46 · A0A2N7BH46_9BACT
- ProteinCoproporphyrinogen-III oxidase
- GenehemN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids447 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 5'-deoxyadenosine + 2 L-methionine + 2 CO2
Cofactor
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53 | S-adenosyl-L-methionine 1 (UniProtKB | ChEBI) | |||
Binding site | 59 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 63 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 65-67 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 66 | [4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 110 | S-adenosyl-L-methionine 1 (UniProtKB | ChEBI) | |||
Binding site | 111-112 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 143 | S-adenosyl-L-methionine 1 (UniProtKB | ChEBI) | |||
Binding site | 170 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 182 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 207 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 241 | S-adenosyl-L-methionine 2 (UniProtKB | ChEBI) | |||
Binding site | 328 | S-adenosyl-L-methionine 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | coproporphyrinogen dehydrogenase activity | |
Molecular Function | coproporphyrinogen oxidase activity | |
Molecular Function | metal ion binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoproporphyrinogen-III oxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Cytophagia > Cytophagales > Cytophagaceae > Siphonobacter
Accessions
- Primary accessionA0A2N7BH46
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length447
- Mass (Da)51,329
- Last updated2018-04-25 v1
- MD5 Checksum7F1E4AC2735FC402A93BBAD7F9C41D65
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NJAG01000002 EMBL· GenBank· DDBJ | PMD99259.1 EMBL· GenBank· DDBJ | Genomic DNA |