A0A2N6N7K2 · A0A2N6N7K2_9COXI
- Protein3-dehydroquinate dehydratase
- GenearoD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids228 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Catalytic activity
- 3-dehydroquinate = 3-dehydroshikimate + H2O
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
Binding site | 34-36 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
Binding site | 64 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
Active site | 118 | Proton donor/acceptor | |||
Active site | 145 | Schiff-base intermediate with substrate | |||
Binding site | 185 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
Binding site | 205 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
Binding site | 209 | 3-dehydroquinate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydroquinate dehydratase activity | |
Biological Process | 3,4-dihydroxybenzoate biosynthetic process | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate dehydratase
- EC number
- Short names3-dehydroquinase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Coxiellaceae
Accessions
- Primary accessionA0A2N6N7K2
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length228
- Mass (Da)26,098
- Last updated2018-04-25 v1
- Checksum0469A26DF0E3F26C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NSHJ01000033 EMBL· GenBank· DDBJ | PMB54967.1 EMBL· GenBank· DDBJ | Genomic DNA |