A0A2N6N6A6 · A0A2N6N6A6_9COXI
- ProteinTransketolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids670 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Catalytic activity
- D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor
Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
Note: Binds 1 thiamine pyrophosphate per subunit.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 26 | substrate | |||
Site | 26 | Important for catalytic activity | |||
Binding site | 261 | substrate | |||
Site | 261 | Important for catalytic activity | |||
Binding site | 358 | substrate | |||
Binding site | 385 | substrate | |||
Binding site | 462 | substrate | |||
Binding site | 470 | substrate | |||
Binding site | 474 | substrate | |||
Binding site | 520 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | metal ion binding | |
Molecular Function | transketolase activity | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTransketolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Coxiellaceae
Accessions
- Primary accessionA0A2N6N6A6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Sequence
- Sequence statusComplete
- Length670
- Mass (Da)74,963
- Last updated2018-04-25 v1
- MD5 ChecksumA8B097FE3E89A84364663F19CF94B688
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NSHJ01000113 EMBL· GenBank· DDBJ | PMB54532.1 EMBL· GenBank· DDBJ | Genomic DNA |