Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A2N6N6A6 · A0A2N6N6A6_9COXI

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site26substrate
Site26Important for catalytic activity
Binding site261substrate
Site261Important for catalytic activity
Binding site358substrate
Binding site385substrate
Binding site462substrate
Binding site470substrate
Binding site474substrate
Binding site520substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • ORF names
      CLERM_411

Organism names

Accessions

  • Primary accession
    A0A2N6N6A6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain355-526Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    670
  • Mass (Da)
    74,963
  • Last updated
    2018-04-25 v1
  • MD5 Checksum
    A8B097FE3E89A84364663F19CF94B688
MPSRQECANAIRTLVIDAVENANSGHPGMPMGMADIAEVLWRDFLKFNPGNPYWVNRDRFILSNGHGAMLQYALLHLTGFDLSIEDLKNFRQFHSRTPGHPEFRHTPGVETTTGPLGQGLANGVGMAIAEQILASMFNREGFPIVDHDTYVFVGDGDLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGDVRGWFTDDTAKRFEAYGWQVISHVDGHDPKIIYQAIIEAKNDISKPTLICCKTIIGYGAPILAGQAVIHGAPLGAEEVSNTRKILNCSYPPFEIPKEIYAAWDAKEKGKKYEAQWNQLFTNYEKDHPELAEEFLRRQKKILSADYTKKIKEFILNSEASKEDNATRKLSLRCLNAIASSLPEIIGGSSDLSESNCTQWSGASILSQENRQGNYIKYGVREFAMTAIVNGIALHGGFIPFAGTFLTFSDYARNAIRLAALTQAHSIFVYSHDSIALGEDGPTHQPIEHLPSLRMIPGLHVWRPCDGTEVAVAWREMIQHHGPSCLVLTRQKVTHQNRNAQQVELITRGGYVLWEATELPQIILIATGSEVMITVEAAKALKQTIPVRVISMPCCEIFKNQDIEYQKLVLPSHITKRIVIEAAYPDYWYQFVGHEGKVIGINQFGASAPYQMIYREYGFTQERIIETVKEFFYEFKIKEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NSHJ01000113
EMBL· GenBank· DDBJ
PMB54532.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help