A0A2N3B3J3 · A0A2N3B3J3_9PROT

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site108-115GTP (UniProtKB | ChEBI)
Binding site191-195GTP (UniProtKB | ChEBI)
Binding site249-252GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle protein
  • EC number
  • Alternative names
    • Fifty-four homolog

Gene names

    • Name
      ffh
    • ORF names
      CVT87_01570

Organism names

Accessions

  • Primary accession
    A0A2N3B3J3

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain270-283SRP54-type proteins GTP-binding
Region466-490Disordered

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    50,894
  • Last updated
    2018-04-25 v1
  • MD5 Checksum
    A4CB83B620311125A9117641011C1AA6
MFDTLSDRLGGVFDKLKGRGALREQDVRDAMREVRIALLEADVALPVARRFIDAVIEKAVGQDVLRSVTPGQQVIKIVHDELIATLGGAETEGLNLDAKPPVVIMMVGLQGSGKTTTTAKLAKLIRERHGKKALMASLDVNRPAAQEQLAVLGGQVDVATLPIVAGQQPVDIARRAMESARLQNFDVLLLDTAGRLHVDDALMAEMKAVASVSAPTEVLLVVDSLTGQDAVNVAQSFSGEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEPFRPASVADRILGMGDVVSLVERAAATIKEEDAEKLARNIEKGKFDLSDLAMQLKQMRSMGGLGMLAGMMPGMKKAKAAMANSGMDDKVLIHMEAIIGSMTAKERANPDLMNAKRKKRVAAGSGTDVQTVNKVLKMHQEMARAMKQIKKLGGLKGLASMFGGGAAGGMGGGGGAGGMPGLGGPGGFGGMGSGGGLPGLGGPPRSKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PHDZ01000068
EMBL· GenBank· DDBJ
PKP65997.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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