A0A2N2R030 · A0A2N2R030_9PROT
- ProteinPhosphoheptose isomerase
- GenegmhA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids200 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous
The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Catalytic activity
- 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55-57 | substrate | |||
Binding site | 64 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 68 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 68 | substrate | |||
Binding site | 97-98 | substrate | |||
Binding site | 123-125 | substrate | |||
Binding site | 128 | substrate | |||
Binding site | 178 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 178 | substrate | |||
Binding site | 186 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | D-sedoheptulose 7-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoheptose isomerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria
Accessions
- Primary accessionA0A2N2R030
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 40-200 | SIS | |||
Sequence similarities
Belongs to the SIS family. GmhA subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length200
- Mass (Da)20,942
- Last updated2018-04-25 v1
- MD5 Checksum45D4815C00C3F255158DA1CD2F425272
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PHCF01000152 EMBL· GenBank· DDBJ | PKO36303.1 EMBL· GenBank· DDBJ | Genomic DNA |