A0A2N1KSU1 · A0A2N1KSU1_9BACT

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site12-14N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site58(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site101(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site103Proton donor
Site144Raises pKa of active site His

GO annotations

AspectTerm
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      BWI96_03630

Organism names

Accessions

  • Primary accession
    A0A2N1KSU1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-181Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    187
  • Mass (Da)
    21,057
  • Last updated
    2018-04-25 v1
  • Checksum
    1E37685EE1E52B5B
MKRIALFASGSGTNVENIAKYFKNHETISVEMVLCNNPAAGVIERAHRLGIPLKLFNREQFRSGEVLSWLQEAQIDWVILAGFLWLIPKNLVAAYPNRILNIHPALLPKYGGKGMYGSFVHEAVVDAKEIESGITIHYVDEHYDEGNILFQKSFVVEPTDTPADVAKKCHALEYEYFPVVIERAINS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NHPP01000002
EMBL· GenBank· DDBJ
PKK38173.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp