A0A2N0UTD6 · A0A2N0UTD6_9FIRM

  • Protein
    NAD kinase
  • Gene
    ppnK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site69Proton acceptor
Binding site69-70NAD+ (UniProtKB | ChEBI)
Binding site74NAD+ (UniProtKB | ChEBI)
Binding site141-142NAD+ (UniProtKB | ChEBI)
Binding site152NAD+ (UniProtKB | ChEBI)
Binding site169NAD+ (UniProtKB | ChEBI)
Binding site171NAD+ (UniProtKB | ChEBI)
Binding site182-187NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular FunctionNAD+ kinase activity
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase

Gene names

    • Name
      ppnK
    • Synonyms
      nadK
    • ORF names
      DW802_06625
      , DW960_07090
      , GMC96_01050
      , RB5AMG_00677

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 5AMG
    • AM32-13AC
    • AM46-2BH
    • BIOML-A2
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Oscillospiraceae > Ruminococcus

Accessions

  • Primary accession
    A0A2N0UTD6

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the NAD kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,754
  • Last updated
    2018-04-25 v1
  • Checksum
    B1156BD2D40B3ADA
MKFALVVNLSKERAIKYAKKISLFLLDKNAEIAMIEECSQYFKGIHIHYSKNITELFEYCDMAITVGGDGTIIHAAKYAAKADKQLIGVNVGRLGFAADVEPHEYEQLERLITGDYTTEERILLDVEVIKEDGSKHYLAVNDAVVARGQLSKTIDLHLTLDGDEISKYRADGLLFATPTGSTAYSLSAGGPILAPKMECILMTPVCPHSLFSRSVLFSGESELSVHVKIPEECCCVLTIDGEKNVPVLATDRVVIRKSDLKLKLALLHNRNFYKLLNEKLKERDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WNAH01000001
EMBL· GenBank· DDBJ
MTR78239.1
EMBL· GenBank· DDBJ
Genomic DNA
NNBY01000031
EMBL· GenBank· DDBJ
PKD30272.1
EMBL· GenBank· DDBJ
Genomic DNA
QSEV01000005
EMBL· GenBank· DDBJ
RGZ96551.1
EMBL· GenBank· DDBJ
Genomic DNA
QSIY01000001
EMBL· GenBank· DDBJ
RHD25156.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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