A0A2M8WXG0 · A0A2M8WXG0_9BURK
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids303 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- NADP+ + shikimate = 3-dehydroshikimate + H+ + NADPH
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 37-39 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: SLS | ||||||
Binding site | 89 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 93 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 105 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 114 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 129 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 153-157 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GAGGA | ||||||
Binding site | 243 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 245 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 266 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 273 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Acidovorax
Accessions
- Primary accessionA0A2M8WXG0
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-116 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: LIGAGIQKSLSPALHEEEARHHGMRLHYQLIDLDRSASSTEHLPTLLSAARIMGYAGCNVTYPCKQAVIPYLDSLSEEARAMGAVNTV | ||||||
Domain | 268-291 | SDH C-terminal | ||||
Sequence: GMAVGQAVGAFELFTGEAPDAARM |
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length303
- Mass (Da)31,829
- Last updated2018-04-25 v1
- Checksum84768FAD6329A013