A0A2M8ITF3 · A0A2M8ITF3_9RHOB

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75Na+ (UniProtKB | ChEBI); structural
Binding site78Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • ORF names
      CVM52_25480

Organism names

  • Taxonomic identifier
  • Strain
    • 157
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Pseudooceanicola

Accessions

  • Primary accession
    A0A2M8ITF3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane35-54Helical
Transmembrane61-80Helical
Transmembrane100-120Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    126
  • Mass (Da)
    12,853
  • Last updated
    2018-04-25 v1
  • Checksum
    345E6B6D782E4F77
MILTVSLVALGGALGASLRYLAGLGVFRLLGPQEFPLAILTVNVLGSLLMGVFVSLAAHKGLTYLSPLVMTGLLGGFTTFSSFSLETVTLIERGATGQAAVYVLASVLLSVGALVAGLLMTRAVLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PGTB01000320
EMBL· GenBank· DDBJ
PJE33814.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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