A0A2M8HLU7 · A0A2M8HLU7_9LEPT

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

1918100200300400500600700800900
TypeIDPosition(s)Description
Binding site87ATP (UniProtKB | ChEBI)
Binding site105-109ATP (UniProtKB | ChEBI)
Binding site494ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      CK427_07660

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FW.030
  • Taxonomic lineage
    Bacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira

Accessions

  • Primary accession
    A0A2M8HLU7

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain3-636SecA family profile
Domain89-247Helicase ATP-binding
Region868-918Disordered
Compositional bias870-908Polar residues

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    918
  • Mass (Da)
    104,140
  • Last updated
    2018-04-25 v1
  • Checksum
    41CFEA2279473686
MIDKLLGFFLGSKHERDMKRIAPIVARINSLEPNLKELSDEMLGKQTIKFKDQLAQGQTLDDILPEAFATVREVSVRTMGMRHFDVQMMGGIALHDGKIAEMKTGEGKTLTSTLAIYLNALAGKGVHVVTVNDYLARRDANWMKPIFEFLGISVGIIQHDMDHKLRQAAYASDITYGTNNEYGFDYLRDNMVSFKEHKVQREHFFAIVDEVDSILIDEARTPLIISGPTDETTDKYTRVNKVIPKLKELEDYELDEKARSALLTEAGVSSVEKLLSIENLYAPENVDLVHHVHQALKAHYIFKKDVDYVVQGGEVIIVDEFTGRLMPGRRYSDGLHQALEAKEAVTIARESQTLASITFQNYFRIYDKLAGMTGTADTEAEEFHKIYSLDVVVIPPNVPVKRIDNGDRVYQTEKEKFSAIADEIKERNSNKQPILVGTVSIEKSEALSHLLTSKGLTHNVLNAKFHEKEAEIIANAGKPGAITIATNMAGRGTDIVLGGSQKYKESIEELAEKHHELIPFRDMVLKNKIEEANLEMARIQKQEFKTHCQTILNEATEWKKKNTIVKEAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLQDDLMRIFGSDRISKIMTSLKMPEGQEIEHPWVSSAIAKAQKRVEGHNFDIRKHLLEYDDVMNRQRMFIYEIRNNILEKESVHSKVTEYIEEITESQILASCEGNNVSAWDLDSLNEWMRSLGIESNITTDSYQKVAKPQLQLFDDVFASLKEAYKNRSVQIGEDVWKSLERNIFLDIMDHRWKEHLYAMDHLRDGIWAVGYGEKNPLVEYKLQGFRMFDAMVESLKQEIITFLFRVEVTENIAIKEESKEYRKIGEEHHQGMSTFGNKSNGGGILPGSSPSELSTKPKVSVSVSAGGASERKSSRRNKRG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias870-908Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PEQN01000012
EMBL· GenBank· DDBJ
PJE02519.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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