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A0A2M8AX34 · A0A2M8AX34_9DELT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

161750100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site198-205ATP (UniProtKB | ChEBI)
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Active site421
Binding site424Zn2+ (UniProtKB | ChEBI); catalytic
Binding site496Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      CO109_13760

Organism names

Accessions

  • Primary accession
    A0A2M8AX34

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-25Helical
Transmembrane105-126Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain190-329AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    617
  • Mass (Da)
    67,356
  • Last updated
    2018-04-25 v1
  • MD5 Checksum
    ADB67B403263EF9C237DF7CB6847FD59
MNQFYRNLAIWMLIALGMVFLFNTFNTKKVEFEEVSFSTFSRDVDDGKVKEVTIKGQEITGKYADNAGKEKKAFHTYAPDDPDLVKNLRGKNVQITARPLDDNPWYMTLLVSWLPMLLLIGVWIFFMRQMQAGGGKAMSFGKSRAKLLTETTNKVTFADVAGIEEAKEELQEIIAFLKDPKRFTKLGGRIPKGVLLVGAPGTGKTLLARAIAGEAGVPFFSISGSDFVEMFVGVGAARVRDLFIQGKKSAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFESNEGLILIAATNRPDVLDPALMRPGRFDRQVIVPKPDVKGREQILGVHTRKIPLDPDVKLDVLAKGTPGFTGADLANLANEAAIHAAGINLAAVTMDCFEMAKDKVMMGRERRSMIISDDEKKSTAYHEAGHAIVATLTPGADPIHKVSIIPRGMALGITQQLPIDERHTYSQVYLKNNITILMGGRVAEELVYGELTTGAGNDIERATALARKMVCEWGMSDKLGPVTFGQKQESIFLGRDITRHQDYSEATSRDIDQEVHGIVIAAYERARTLLGTHIDILHRVAKTLLEKEVVDGAEIQRIIGGGNLPEGPADAPAPAGAPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PFUH01000403
EMBL· GenBank· DDBJ
PJB30754.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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