A0A2M8AX20 · A0A2M8AX20_9DELT
- ProteintRNA(Ile)-lysidine synthase
- GenetilS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids524 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Catalytic activity
- cytidine34 in tRNA(Ile2) + L-lysine + ATP = lysidine34 in tRNA(Ile2) + AMP + diphosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46-51 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | tRNA(Ile)-lysidine synthase activity | |
Biological Process | tRNA modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA(Ile)-lysidine synthase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Deltaproteobacteria
Accessions
- Primary accessionA0A2M8AX20
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | |||
Region | 1-33 | Disordered | |||
Compositional bias | 275-290 | Polar residues | |||
Region | 275-296 | Disordered | |||
Domain | 438-520 | Lysidine-tRNA(Ile) synthetase C-terminal | |||
Domain
The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.
Sequence similarities
Belongs to the tRNA(Ile)-lysidine synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length524
- Mass (Da)57,875
- Last updated2018-04-25 v1
- ChecksumCE4086086C3677DB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | |||
Compositional bias | 275-290 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PFUH01000403 EMBL· GenBank· DDBJ | PJB30755.1 EMBL· GenBank· DDBJ | Genomic DNA |