A0A2M7SFQ4 · A0A2M7SFQ4_9DELT

Function

function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).

Miscellaneous

The active site is located at the dimer interface.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site139substrate
Binding site140substrate
Binding site169a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site214a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site269a divalent metal cation (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site277substrate
Binding site286substrate
Binding site295substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-hydroxythreonine-4-phosphate dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Biological Processpyridoxal phosphate biosynthetic process
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxythreonine-4-phosphate dehydrogenase
  • EC number
  • Alternative names
    • 4-(phosphohydroxy)-L-threonine dehydrogenase

Gene names

    • Name
      pdxA
    • ORF names
      COY50_15705

Organism names

Accessions

  • Primary accession
    A0A2M7SFQ4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the PdxA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    345
  • Mass (Da)
    37,054
  • Last updated
    2018-04-25 v1
  • Checksum
    9F4FD063EB3CDBCE
MELPVIGITMGDPAGVGPEIIVKALSDPQIFKICRPLVLGDQGIIAKAAQILGLEIKVNVAKDIRSGRYEVGAINVLNLSNLDASAVAWGKPDERFGKAVVGYIKAGTKLALEGETEAITTAPINKEVINRAGYAYAGHTELFAELTHTKDYVMMLTGEKLRVALVTTHCRLKDVAALLNTQRIFTIIKVTNNSLKEYFAISKPRIAVASLNPHAGEGGMFGDEEDRIIAPAINRAKDAGIHAIGPLPSDTLFYYASRGDYDVVVCMYHDQGLIPLKLLSFQNAVNVTLGLPIIRTSVDHGTAYDIAGTGKANPESLKKAITLAASMANKRRKLSKDMSGNLTLC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PFMT01000457
EMBL· GenBank· DDBJ
PIZ18367.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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