A0A2L2K7I0 · A0A2L2K7I0_9VIBR

  • Protein
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • Gene
    panB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site45Mg2+ (UniProtKB | ChEBI)
Binding site45-463-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site843-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site84Mg2+ (UniProtKB | ChEBI)
Binding site1123-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site114Mg2+ (UniProtKB | ChEBI)
Active site181Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • ORF names
      CYQ91_13735
      , JOS67_03560

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JBS-8-11-1
    • SLV18
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio > Vibrio diabolicus subgroup

Accessions

  • Primary accession
    A0A2L2K7I0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Family & Domains

Sequence similarities

Belongs to the PanB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    28,748
  • Last updated
    2018-06-20 v1
  • Checksum
    BE17172469268F3F
MKKMTINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGHNDTLPVTVDDIAYHTRCVRAGSPNCLLMADMPFMSYTTPEQACENAATLMRAGANMVKIEGGDWLVDTVKMLTERSVPVCAHLGLTPQAVNIFGGYKVQGRDQEKADRMVKDALALQEAGAQIVLLECVPAELAERITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDMRKAVAKYIEDVANGVFPDDAHTIA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP069195
EMBL· GenBank· DDBJ
QRG83393.1
EMBL· GenBank· DDBJ
Genomic DNA
PKPZ01000012
EMBL· GenBank· DDBJ
RPB38550.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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