A0A2L1L6K7 · A0A2L1L6K7_9INFA

  • Protein
    RNA-directed RNA polymerase catalytic subunit
  • Gene
    PB1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copies vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular Functionnucleotide binding
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processsymbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
Biological Processviral RNA genome replication
Biological Processviral transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase catalytic subunit
  • EC number
  • Alternative names
    • Polymerase basic protein 1
      (PB1
      )
    • RNA-directed RNA polymerase subunit P1

Gene names

    • Name
      PB1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • A/chicken/Minnesota/15-014297-1/2015
    • A/ring-necked duck/Kentucky/15-012967-1/2015
    • A/snow goose/Kentucky/15-012967-2/2015
    • A/turkey/Iowa/15-014119-1/2015
    • A/turkey/Minnesota/15-010915-1/2015
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae

Accessions

  • Primary accession
    A0A2L1L6K7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

Phosphorylated by host PRKCA.

Keywords

Interaction

Subunit

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation.

Family & Domains

Features

Showing features for compositional bias, region, motif, domain.

TypeIDPosition(s)Description
Compositional bias51-65Polar residues
Region51-82Disordered
Motif187-195Nuclear localization signal
Motif203-216Nuclear localization signal
Region249-256Promoter-binding site
Domain286-483RdRp catalytic

Sequence similarities

Belongs to the influenza viruses polymerase PB1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    86,385
  • Last updated
    2018-04-25 v1
  • Checksum
    290D0269D8B89774
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNSETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRDQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias51-65Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG964662
EMBL· GenBank· DDBJ
AVE28803.1
EMBL· GenBank· DDBJ
Viral cRNA
MG964814
EMBL· GenBank· DDBJ
AVE29031.1
EMBL· GenBank· DDBJ
Viral cRNA
MG964822
EMBL· GenBank· DDBJ
AVE29043.1
EMBL· GenBank· DDBJ
Viral cRNA
MG964854
EMBL· GenBank· DDBJ
AVE29091.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965078
EMBL· GenBank· DDBJ
AVE29427.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965110
EMBL· GenBank· DDBJ
AVE29475.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965126
EMBL· GenBank· DDBJ
AVE29499.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965142
EMBL· GenBank· DDBJ
AVE29523.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965158
EMBL· GenBank· DDBJ
AVE29547.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965198
EMBL· GenBank· DDBJ
AVE29607.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965214
EMBL· GenBank· DDBJ
AVE29631.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965222
EMBL· GenBank· DDBJ
AVE29643.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965262
EMBL· GenBank· DDBJ
AVE29703.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965270
EMBL· GenBank· DDBJ
AVE29715.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965294
EMBL· GenBank· DDBJ
AVE29751.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965334
EMBL· GenBank· DDBJ
AVE29811.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965342
EMBL· GenBank· DDBJ
AVE29823.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965350
EMBL· GenBank· DDBJ
AVE29835.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965374
EMBL· GenBank· DDBJ
AVE29871.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965390
EMBL· GenBank· DDBJ
AVE29895.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965430
EMBL· GenBank· DDBJ
AVE29955.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965454
EMBL· GenBank· DDBJ
AVE29991.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965510
EMBL· GenBank· DDBJ
AVE30075.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965526
EMBL· GenBank· DDBJ
AVE30099.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965566
EMBL· GenBank· DDBJ
AVE30159.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965830
EMBL· GenBank· DDBJ
AVE30555.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965838
EMBL· GenBank· DDBJ
AVE30567.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965854
EMBL· GenBank· DDBJ
AVE30591.1
EMBL· GenBank· DDBJ
Viral cRNA
MG965862
EMBL· GenBank· DDBJ
AVE30603.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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