A0A2L1DGG0 · HSTX1_HAESL

Function

function

Leech salivary gland peptide with unknown function (PubMed:32524995).
It was originally described as exhibiting analgesic function by specifically inhibiting rodent Nav1.8/SCN10A and Nav1.9/SCN11A voltage-gated sodium channels, as well as showing analgesic activities in several mouse models (PubMed:29559913).
In a second study, the synthetic peptide has been shown as having very weak activity on Nav1.8/SCN10A at the highest concentration tested (90 uM) and as being only very modestly active at hNav1.9/SCN11A, with a modest peak current size reduction (~19%) at high concentrations (10 uM) (PubMed:32524995).
In addition, this second study reports no analgesic activity in a mouse model of inflammatory pain (PubMed:32524995).

Miscellaneous

Does not show effect on voltage-gated calcium channels, potassium channels, and tetrodotoxin-sensitive sodium channels (PubMed:29559913).
Does not show activity on Nav1.7/SCN9A, and shows very weak activity on cation channel TRPA1 (PubMed:32524995).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Names & Taxonomy

Protein names

  • Recommended name
    Peptide HSTX-I

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Hirudinea > Hirudinida > Hirudiniformes > Haemadipsidae > Haemadipsa

Accessions

  • Primary accession
    A0A2L1DGG0

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, peptide, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-21
PropeptidePRO_000045221522-28
PeptidePRO_501499241326-48Peptide HSTX-I
Disulfide bond27↔39
Disulfide bond33↔44
Modified residue48Isoleucine amide

Keywords

Expression

Tissue specificity

Expressed in salivary glands. Highly expressed in the head, body and tail with a 2-3-fold higher expression in the head.

Family & Domains

Sequence similarities

Belongs to the annelide toxin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    49
  • Mass (Da)
    5,409
  • Last updated
    2021-04-07 v2
  • Checksum
    38DF53B293A9C102
MRTLLVFLLLAIFVAVLIGNVQVEAACKEYWECGAFLFCIEGICVPMIG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict8in Ref. 1; AVC68883

Mass Spectrometry

Molecular mass is 2,621.14 Da. Determined by MALDI.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG786826
EMBL· GenBank· DDBJ
AVC68883.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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