A0A2L0UCP9 · A0A2L0UCP9_9MICC

  • Protein
    Probable cytosol aminopeptidase
  • Gene
    pepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site275Mn2+ 2 (UniProtKB | ChEBI)
Binding site280Mn2+ 2 (UniProtKB | ChEBI)
Binding site280Mn2+ 1 (UniProtKB | ChEBI)
Active site287
Binding site298Mn2+ 2 (UniProtKB | ChEBI)
Binding site357Mn2+ 1 (UniProtKB | ChEBI)
Binding site359Mn2+ 1 (UniProtKB | ChEBI)
Binding site359Mn2+ 2 (UniProtKB | ChEBI)
Active site361

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      CVO76_04790

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UMCV2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Arthrobacter

Accessions

  • Primary accession
    A0A2L0UCP9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain355-362Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    515
  • Mass (Da)
    52,907
  • Last updated
    2018-04-25 v1
  • Checksum
    7BE3BEAE4231BBB1
MIKTTELHLTASAKDLKKIPSDALVIAVAKGTDGPVLLDSPLPPKAARALGDSLQVLGITGAADEVRRLPGLPDTGADSLVLSGVGTVADGEALSPETLRRAAGAAVRQLTGLETVVLALPAGTAAAAAAVAEGAAFGAYSYEGHKSGIRADGTVAPSKDQAAVRTVVVHTSAADDADLAPAFRRASILGKNVNATRSLVNQPPSHLYPETFAQAAKDLSRGLPVKVTVMDEKRLERDGYGGILGVGKGSTRPPRMVKVEYSPANSAVHLALVGKGITFDSGGLSLKPAAGMQTMKLDMAGAAVVLTTLLAVAELGLPAKVTAWLCLAENMPSGSAQRPEDVLSIYGGRTVEVLNTDAEGRLVMADGLAAASEESPDAIIDIATLTGAQMIALGTRVSGVMGDDGVRDAVKAAADRAGEQFWPMPLPEELRPSLESQVADIANIGERHGGMMTAAVFLREFVGQVDGEKIPWAHLDIAGPAFNEGAPYGYTPKAGTGVGVRTLLAYVEDVLARTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024915
EMBL· GenBank· DDBJ
AUZ87024.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp