A0A2L0H3P8 · A0A2L0H3P8_RHIFR
- ProteinSiroheme synthase
- GenecysG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids485 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin
Pathway
Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.
Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 251 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 273 | Proton donor | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NAD binding | |
Molecular Function | precorrin-2 dehydrogenase activity | |
Molecular Function | sirohydrochlorin ferrochelatase activity | |
Molecular Function | uroporphyrin-III C-methyltransferase activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | methylation | |
Biological Process | siroheme biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium
Accessions
- Primary accessionA0A2L0H3P8
Proteomes
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 154-211 | Sirohaem synthase dimerisation | ||||
Sequence: SLGIVATLAASYREAVDRLIPRGVARRVFWRRFFSGPVADHVALGDLASARREASRLL | ||||||
Domain | 221-430 | Tetrapyrrole methylase | ||||
Sequence: VWLVGAGPGAEDLLTLRAQRVMMEADAIVYDALVPQAIVDMGRRDAERLSVGKRKGCHTKSQDEINHLLVKLAKEGKRVVRLKSGDPLIFGRAGEEMAAMREAGVSYEIVPGITSAFAAAADFELPLTLRGVASSLVFTTGHDLAGDVLPDWARLAVSGATIAVYMGRSVAASVAGRLMQAGLPAETTVAVIENASRPERRLLHGILREL | ||||||
Region | 462-485 | Disordered | ||||
Sequence: LAAGRRKGAGPSASGAHRAEHILN |
Sequence similarities
Belongs to the precorrin methyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)51,675
- Last updated2018-04-25 v1
- Checksum88699A33DC2EB96C