A0A2K9VRQ0 · A0A2K9VRQ0_TETTT
- ProteinNADH-quinone oxidoreductase subunit N
- GenendhB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids510 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | plasma membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit N
- EC number
- Alternative names
Gene names
Encoded on
- Plastid
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Aizoaceae > Tetragonia
Accessions
- Primary accessionA0A2K9VRQ0
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-47 | Helical | ||||
Sequence: FHLLLFDGSFIFPECILIFGLILLLM | ||||||
Transmembrane | 59-79 | Helical | ||||
Sequence: WLYFISSTSLVMSITALLFRW | ||||||
Transmembrane | 99-119 | Helical | ||||
Sequence: IFQFLILLCSTLCIPLSVEYI | ||||||
Transmembrane | 126-143 | Helical | ||||
Sequence: LTEFLLFVLTATLGGMFL | ||||||
Transmembrane | 223-244 | Helical | ||||
Sequence: MYNSPGISIALIFITVGIGFKL | ||||||
Transmembrane | 296-316 | Helical | ||||
Sequence: HLLLEILAILSMILGNLIAIT | ||||||
Transmembrane | 323-342 | Helical | ||||
Sequence: MLAYSSIGQIGYVIIGIIVG | ||||||
Transmembrane | 348-372 | Helical | ||||
Sequence: YASMITYMLFYISMNLGTFACIVLF | ||||||
Transmembrane | 393-415 | Helical | ||||
Sequence: FLALSLALCLLSLGGLPPLAGFF | ||||||
Transmembrane | 427-448 | Helical | ||||
Sequence: AGLYFLVLIGLFTSVLSIYYYL | ||||||
Transmembrane | 480-505 | Helical | ||||
Sequence: IELSMIVCVIASTIPGISMNPIIAIA |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-117 | NAD(P)H-quinone oxidoreductase subunit 2 N-terminal | ||||
Sequence: FMKAFHLLLFDGSFIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVE | ||||||
Domain | 146-443 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDANDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLFTSVLS |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length510
- Mass (Da)56,709
- Last updated2018-04-25 v1
- Checksum18296A0EFEE688F2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MF975369 EMBL· GenBank· DDBJ | AUV65145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF975369 EMBL· GenBank· DDBJ | AUV65146.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK397903 EMBL· GenBank· DDBJ | QBC70523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK397903 EMBL· GenBank· DDBJ | QBC70524.1 EMBL· GenBank· DDBJ | Genomic DNA |