A0A2K9RFZ9 · TPS6_VITAC

Function

function

Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders (e.g. premenstrual syndrome and mastodynia) (Probable). Terpene synthase the catalyzes the conversion of peregrinol diphosphate to labda-1316,14-dien-9-ol, and of syn-copalyl diphosophate to dehydroabietadiene and syn-isopimara-7,15-diene (PubMed:29315936).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 3 Mg2+ ions per subunit.

Pathway

Secondary metabolite biosynthesis; terpenoid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site330Mg2+ 1 (UniProtKB | ChEBI)
Binding site330Mg2+ 2 (UniProtKB | ChEBI)
Binding site334Mg2+ 1 (UniProtKB | ChEBI)
Binding site334Mg2+ 2 (UniProtKB | ChEBI)
Binding site474Mg2+ 3 (UniProtKB | ChEBI)
Binding site477Mg2+ 3 (UniProtKB | ChEBI)
Binding site482Mg2+ 3 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast
Molecular FunctionLabd-13(16),14-diene-9-ol synthase activity
Molecular Functionmagnesium ion binding
Molecular Functionsyn-isopimara-7,15-diene synthase activity
Molecular Functionterpene synthase activity
Biological Processgibberellin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Class I diterpene synthase TPS6, chloroplastic
  • Alternative names
    • Labd-13(16),14-diene-9-ol synthase
      (EC:4.2.3.-
      ) . EC:4.2.3.- (UniProtKB | ENZYME | Rhea)
    • Syn-isopimara-7,15-diene synthase
      (EC:4.2.3.-
      ) . EC:4.2.3.- (UniProtKB | ENZYME | Rhea)
    • Terpene synthase 6
      (VacTPS6
      )

Gene names

    • Name
      TPS6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Lamiaceae > Viticoideae > Vitex

Accessions

  • Primary accession
    A0A2K9RFZ9

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004493121-594Class I diterpene synthase TPS6, chloroplastic

Expression

Tissue specificity

Mostly expressed in trichomes of leaves and fruits.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif330-334DDXXD motif

Domain

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similarities

Belongs to the terpene synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    69,281
  • Last updated
    2018-04-25 v1
  • Checksum
    24C183A37ED574D9
MSLRFNLIVTPFSNYEIRNRRETFPVQKFLMTTSKSAIKVKCSLKTSIDLVGKIREKINGKVDNSLEVPTINYLVDIPSNLCMIDSLERLGVARYFQSEIDGVLEKTYRLWQQREKDIFADVTCRAMAFRFLRVKGYEVSSDELAPYADQVHVNPQISDVTTVVELYRASQVRIYEEDSILEKLHAWTSTFLKQQLQSKTISDKKLHEQVEYYLKNYHGIQNQVAVRRSLDLYDIDHYPILKVADRFRIIYNEDFFVFLRQDFNLCQAQHQKELQQLQRWYEDCRLDTLNYGRNVVHVSCFLAAANFGDPELSNARLAFAKTIVLVTRIDDFFDLAGSREESYKILELVKEWKEKPTEDYGSKEVEILFTALYDTVNEFAEIAYIEQGRCVKPLLIKLWVELLTSFKKELDSWTDDTALTLDEYLSSAWMSIACRVCTLTALQFLGVKLSEEMLSSQECTDLCRHLSFVNRLLNDVQTFERERKENTINAVSVLLAAHRHERAITEEEAISKIQEIVEQNRRKLMRMVYQRESVFPRKCRNVFLEVSKMGHYLYASGDELTTPQQLMEDMKSLVFEPLALHPLETNNVIASGKN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG696753
EMBL· GenBank· DDBJ
AUT77125.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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