A0A2K8T0G8 · A0A2K8T0G8_9NOSO

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site198-201CoA (UniProtKB | ChEBI)
Binding site319CoA (UniProtKB | ChEBI)
Binding site395-397ATP (UniProtKB | ChEBI)
Binding site419-424ATP (UniProtKB | ChEBI)
Binding site513ATP (UniProtKB | ChEBI)
Binding site528ATP (UniProtKB | ChEBI)
Binding site536CoA (UniProtKB | ChEBI)
Binding site539ATP (UniProtKB | ChEBI)
Binding site550Mg2+ (UniProtKB | ChEBI)
Binding site552Mg2+ (UniProtKB | ChEBI)
Binding site555Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acsA
    • ORF names
      COO91_07241

Organism names

Accessions

  • Primary accession
    A0A2K8T0G8

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue622N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-88Acetyl-coenzyme A synthetase N-terminal
Domain96-484AMP-dependent synthetase/ligase
Domain544-622AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    657
  • Mass (Da)
    72,954
  • Last updated
    2018-04-25 v1
  • Checksum
    3EB4AB5BF9B7A7AE
MSQPTIESILQENRLFHPASEFSQNAHIKSLEDYQRLYDKAKADPQQFWADLAGTELEWFQKWDTVLDWQPPFAKWFVGGKMNISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQLHREVCQFANVLKQLGVKKGDRVGIYMPMIPEAAIAMLACARIGAPHGVVFGGFSAEALRDRLIDATAKLVITADGGWRKDAIVPLKEQVDKALADGAVPSVENVLVVKRTGQETYMQLGGRDHWWHDLQKGVSADCPAEPMDSEDMLFVLYTSGSTGKPKGVVHTTAGYNLYTHITTKWIFDLQDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGAPRASNPGCFWDVIEKYGVNIFYTAPTAIRAFIKMGEQHPNARNLSSLRLLGSVGEPINPEAWMWYHKVIGGDRCPIVDTWWQTETGGIMITPLPGAIPTKPGSATLPFPGIIADVVDLEGNTVPNNEGGYLAVRHPWPGMMRTVYGDPERFCRTYWEHIPPKDGNYTYFAGDGARQDEDGYFWVMGRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDELKGEEVVAFVTLEGTYQASEELSKELKLHVVKEIGAIARPGEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLEDKSVLDKLREGS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024785
EMBL· GenBank· DDBJ
AUB41196.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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