A0A2K6P6Q6 · A0A2K6P6Q6_RHIRO
- ProteinMelanocyte inducing transcription factor
- GeneMITF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids526 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Cellular Component | nucleus | |
Cellular Component | protein-containing complex | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | E-box binding | |
Molecular Function | protein dimerization activity | |
Biological Process | melanocyte differentiation | |
Biological Process | negative regulation of cell migration | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of DNA-templated transcription initiation | |
Biological Process | positive regulation of gene expression | |
Biological Process | protein-containing complex assembly |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Rhinopithecus
Accessions
- Primary accessionA0A2K6P6Q6
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-54 | Disordered | ||||
Sequence: MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMT | ||||||
Compositional bias | 11-26 | Basic and acidic residues | ||||
Sequence: FEVGEEFHEEPKTYYE | ||||||
Compositional bias | 28-54 | Polar residues | ||||
Sequence: KSQPLKSSSSAEHPGASKPPISSSSMT | ||||||
Coiled coil | 60-88 | |||||
Sequence: RQQLMREQMQEQERREQQQKLQAAQFMQQ | ||||||
Domain | 311-364 | BHLH | ||||
Sequence: QKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKL | ||||||
Coiled coil | 357-398 | |||||
Sequence: SVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQ | ||||||
Compositional bias | 496-515 | Polar residues | ||||
Sequence: TDPLLSSVSPGASKTSSRRS | ||||||
Region | 496-526 | Disordered | ||||
Sequence: TDPLLSSVSPGASKTSSRRSSMSMEETEHAC |
Sequence similarities
Belongs to the MiT/TFE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length526
- Mass (Da)58,752
- Last updated2018-03-28 v1
- ChecksumC94340DDAFD2BCBD
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K6P6V8 | A0A2K6P6V8_RHIRO | MITF | 419 | ||
A0A2K6P6R5 | A0A2K6P6R5_RHIRO | MITF | 519 | ||
A0A2K6P6Q8 | A0A2K6P6Q8_RHIRO | MITF | 517 | ||
A0A2K6P6S0 | A0A2K6P6S0_RHIRO | MITF | 504 | ||
A0A2K6P6S1 | A0A2K6P6S1_RHIRO | MITF | 91 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-26 | Basic and acidic residues | ||||
Sequence: FEVGEEFHEEPKTYYE | ||||||
Compositional bias | 28-54 | Polar residues | ||||
Sequence: KSQPLKSSSSAEHPGASKPPISSSSMT | ||||||
Compositional bias | 496-515 | Polar residues | ||||
Sequence: TDPLLSSVSPGASKTSSRRS |
Keywords
- Technical term