A0A2K6NYT4 · A0A2K6NYT4_RHIRO

Function

Catalytic activity

  • S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N6-[NEDD8-protein]-yl-[cullin]-L-lysine.
    EC:2.3.2.32 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein neddylation.
Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCul2-RING ubiquitin ligase complex
Cellular ComponentCul3-RING ubiquitin ligase complex
Cellular ComponentCul4A-RING E3 ubiquitin ligase complex
Cellular ComponentCul4B-RING E3 ubiquitin ligase complex
Cellular ComponentCul5-RING ubiquitin ligase complex
Cellular ComponentCul7-RING ubiquitin ligase complex
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular ComponentSCF ubiquitin ligase complex
Molecular Functioncullin family protein binding
Molecular FunctionNEDD8 ligase activity
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Molecular Functionubiquitin protein ligase binding
Molecular Functionubiquitin-ubiquitin ligase activity
Molecular Functionzinc ion binding
Biological Processcellular response to amino acid stimulus
Biological Processnegative regulation of response to oxidative stress
Biological Processnegative regulation of type I interferon production
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processpositive regulation of protein autoubiquitination
Biological Processpositive regulation of TORC1 signaling
Biological Processprotein K48-linked ubiquitination
Biological Processprotein monoubiquitination
Biological Processprotein neddylation
Biological ProcessSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Processspermatogenesis
Biological ProcessT cell activation
Biological Processubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    cullin-RING-type E3 NEDD8 transferase
  • EC number

Gene names

    • Name
      RBX1

Organism names

Accessions

  • Primary accession
    A0A2K6NYT4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain53-98RING-type

Sequence similarities

Belongs to the RING-box family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    108
  • Mass (Da)
    12,274
  • Last updated
    2018-03-28 v1
  • Checksum
    30FC5ADF66096C0E
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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