A0A2K6MKQ1 · A0A2K6MKQ1_RHIBE

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi apparatus
Cellular Componentmitochondrial outer membrane
Cellular Componentprotein phosphatase type 1 complex
Molecular Functionprotein kinase binding
Molecular Functionprotein phosphatase 1 binding
Molecular Functionprotein phosphatase activator activity
Biological Processapoptotic process
Biological Processpositive regulation of phosphoprotein phosphatase activity
Biological Processprotein localization to endoplasmic reticulum
Biological Processregulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
Biological Processregulation of translational initiation in response to stress
Biological Processresponse to endoplasmic reticulum stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein phosphatase 1 regulatory subunit 15A
  • Alternative names
    • Growth arrest and DNA damage-inducible protein GADD34

Gene names

    • Name
      PPP1R15A

Organism names

Accessions

  • Primary accession
    A0A2K6MKQ1

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Mitochondrion outer membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with PPP1CA. Interacts with EIF2S1. Interacts with PCNA. Interacts with LYN and KMT2A/MLL1. Interacts with PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. Interacts with NOX4.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region66-312Disordered
Compositional bias75-89Basic and acidic residues
Compositional bias154-189Basic and acidic residues
Compositional bias204-226Polar residues
Compositional bias229-244Basic and acidic residues
Compositional bias246-260Polar residues
Compositional bias264-284Basic and acidic residues
Region343-553Disordered
Compositional bias349-375Acidic residues
Compositional bias396-412Acidic residues
Compositional bias439-462Acidic residues
Compositional bias514-528Pro residues
Compositional bias533-553Basic and acidic residues
Domain550-620Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Region646-676Disordered

Sequence similarities

Belongs to the PPP1R15 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    676
  • Mass (Da)
    73,825
  • Last updated
    2018-03-28 v1
  • Checksum
    314E3EA7F50763D9
MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPPEPWLVEAVKGAALVEAGLEGEARTPLATPHTPWGRHPDEEAEEGGGPGENRETLGLKTSSSLPEAWGLLDDDDDMYSEREAASVPRGQGSRFADGQPAPLSPSLLIRRLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPRSHRECCPAVEEEDDEEAVKKETGRTSTSALSPGSKPSTWASCPGEEENQATEDERRIEKSKGARKNSVSPPSSGSNPRAWEYRSGEVSEEKEEKAHEEAGKGETAPGPRSSPPAQRPQLKSWWCQPSDEEEGEVKILGAAEKDGEAECPPCIPPSSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASCSTPATGIFWKSWVYRPGEDTEEEEDEDSDTGSAEDEREAEISTSTPPASAFLKAWVYRPGEDPEEEEDEDVGSEDKEDDSEAAVGEAESDPHPSHLAQSAHFRGWVYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETSTRDLDPETPLKARKVHFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRIAQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPLSQFQATPLSQAVATPSPSSPGAAAAPLDLIGRRG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias75-89Basic and acidic residues
Compositional bias154-189Basic and acidic residues
Compositional bias204-226Polar residues
Compositional bias229-244Basic and acidic residues
Compositional bias246-260Polar residues
Compositional bias264-284Basic and acidic residues
Compositional bias349-375Acidic residues
Compositional bias396-412Acidic residues
Compositional bias439-462Acidic residues
Compositional bias514-528Pro residues
Compositional bias533-553Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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