A0A2K6MKQ1 · A0A2K6MKQ1_RHIBE
- ProteinProtein phosphatase 1 regulatory subunit 15A
- GenePPP1R15A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids676 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | protein phosphatase type 1 complex | |
Molecular Function | protein kinase binding | |
Molecular Function | protein phosphatase 1 binding | |
Molecular Function | protein phosphatase activator activity | |
Biological Process | apoptotic process | |
Biological Process | positive regulation of phosphoprotein phosphatase activity | |
Biological Process | protein localization to endoplasmic reticulum | |
Biological Process | regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation | |
Biological Process | regulation of translational initiation in response to stress | |
Biological Process | response to endoplasmic reticulum stress |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein phosphatase 1 regulatory subunit 15A
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Rhinopithecus
Accessions
- Primary accessionA0A2K6MKQ1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Peripheral membrane protein
Mitochondrion outer membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with PPP1CA. Interacts with EIF2S1. Interacts with PCNA. Interacts with LYN and KMT2A/MLL1. Interacts with PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. Interacts with NOX4.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 66-312 | Disordered | ||||
Sequence: TPLATPHTPWGRHPDEEAEEGGGPGENRETLGLKTSSSLPEAWGLLDDDDDMYSEREAASVPRGQGSRFADGQPAPLSPSLLIRRLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPRSHRECCPAVEEEDDEEAVKKETGRTSTSALSPGSKPSTWASCPGEEENQATEDERRIEKSKGARKNSVSPPSSGSNPRAWEYRSGEVSEEKEEKAHEEAGKGETAPGPRSSPPAQRPQLKSWWCQPSDEEE | ||||||
Compositional bias | 75-89 | Basic and acidic residues | ||||
Sequence: WGRHPDEEAEEGGGP | ||||||
Compositional bias | 154-189 | Basic and acidic residues | ||||
Sequence: SDKNPGEEKAEEEGVAEEEGVNKFSYPRSHRECCPA | ||||||
Compositional bias | 204-226 | Polar residues | ||||
Sequence: GRTSTSALSPGSKPSTWASCPGE | ||||||
Compositional bias | 229-244 | Basic and acidic residues | ||||
Sequence: NQATEDERRIEKSKGA | ||||||
Compositional bias | 246-260 | Polar residues | ||||
Sequence: KNSVSPPSSGSNPRA | ||||||
Compositional bias | 264-284 | Basic and acidic residues | ||||
Sequence: RSGEVSEEKEEKAHEEAGKGE | ||||||
Region | 343-553 | Disordered | ||||
Sequence: WVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASCSTPATGIFWKSWVYRPGEDTEEEEDEDSDTGSAEDEREAEISTSTPPASAFLKAWVYRPGEDPEEEEDEDVGSEDKEDDSEAAVGEAESDPHPSHLAQSAHFRGWVYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETSTRDLDPETPLK | ||||||
Compositional bias | 349-375 | Acidic residues | ||||
Sequence: EDTEEEEDEEEDEDSDSGSDEEEGEAE | ||||||
Compositional bias | 396-412 | Acidic residues | ||||
Sequence: EDTEEEEDEDSDTGSAE | ||||||
Compositional bias | 439-462 | Acidic residues | ||||
Sequence: EDPEEEEDEDVGSEDKEDDSEAAV | ||||||
Compositional bias | 514-528 | Pro residues | ||||
Sequence: VPGEKPPPPWAPPRL | ||||||
Compositional bias | 533-553 | Basic and acidic residues | ||||
Sequence: QRRLKRPETSTRDLDPETPLK | ||||||
Domain | 550-620 | Protein phosphatase 1 regulatory subunit 15A/B C-terminal | ||||
Sequence: TPLKARKVHFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRIAQAQEELSPCLTPAARARAWARL | ||||||
Region | 646-676 | Disordered | ||||
Sequence: QATPLSQAVATPSPSSPGAAAAPLDLIGRRG |
Sequence similarities
Belongs to the PPP1R15 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length676
- Mass (Da)73,825
- Last updated2018-03-28 v1
- Checksum314E3EA7F50763D9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 75-89 | Basic and acidic residues | ||||
Sequence: WGRHPDEEAEEGGGP | ||||||
Compositional bias | 154-189 | Basic and acidic residues | ||||
Sequence: SDKNPGEEKAEEEGVAEEEGVNKFSYPRSHRECCPA | ||||||
Compositional bias | 204-226 | Polar residues | ||||
Sequence: GRTSTSALSPGSKPSTWASCPGE | ||||||
Compositional bias | 229-244 | Basic and acidic residues | ||||
Sequence: NQATEDERRIEKSKGA | ||||||
Compositional bias | 246-260 | Polar residues | ||||
Sequence: KNSVSPPSSGSNPRA | ||||||
Compositional bias | 264-284 | Basic and acidic residues | ||||
Sequence: RSGEVSEEKEEKAHEEAGKGE | ||||||
Compositional bias | 349-375 | Acidic residues | ||||
Sequence: EDTEEEEDEEEDEDSDSGSDEEEGEAE | ||||||
Compositional bias | 396-412 | Acidic residues | ||||
Sequence: EDTEEEEDEDSDTGSAE | ||||||
Compositional bias | 439-462 | Acidic residues | ||||
Sequence: EDPEEEEDEDVGSEDKEDDSEAAV | ||||||
Compositional bias | 514-528 | Pro residues | ||||
Sequence: VPGEKPPPPWAPPRL | ||||||
Compositional bias | 533-553 | Basic and acidic residues | ||||
Sequence: QRRLKRPETSTRDLDPETPLK |
Keywords
- Technical term