A0A2K6LK76 · A0A2K6LK76_RHIBE
- ProteinSulfhydryl oxidase
- GeneQSOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids747 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Catalytic activity
- 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular exosome | |
Cellular Component | Golgi membrane | |
Cellular Component | intercellular bridge | |
Molecular Function | FAD binding | |
Molecular Function | flavin-dependent sulfhydryl oxidase activity | |
Molecular Function | protein disulfide isomerase activity | |
Biological Process | extracellular matrix assembly | |
Biological Process | negative regulation of macroautophagy | |
Biological Process | protein folding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfhydryl oxidase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Rhinopithecus
Accessions
- Primary accessionA0A2K6LK76
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 714-731 | Helical | ||||
Sequence: VGLYSLSFMGLLAMYTYF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MGRCGRGSEPLPSLLLLLLLLLAVPGAGA | ||||||
Chain | PRO_5014386888 | 30-747 | Sulfhydryl oxidase | |||
Sequence: APRSALYSPSDPLTLLQADTVRGAVLGSRGAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALNLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFSKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNKEEYLALIFEKGGSYLGREVALDLSQHKGVTVRRVLNTEADVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKFADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAQEVLPAIRGYVHYFFGCRDCAGHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLRFLKAHFSPSNIILDFPAAGSAARREAQNVAAAPELAMGSLELEGRNSTLDPGKPEMMKSPANTTPDVPVERPEASRPPKLRPGLGAAPGQEPPEHMAELQRKEWEQPRGQWHLSKRDTGAALLAESRAEKNHLWGPSEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSHLDISLCVGLYSLSFMGLLAMYTYFRAKIRALKGHVGHPAA |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-156 | Thioredoxin | ||||
Sequence: YSPSDPLTLLQADTVRGAVLGSRGAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALNLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFSKNGSGAVFPVAGADVQTLRERLIDALES | ||||||
Domain | 396-503 | ERV/ALR sulfhydryl oxidase | ||||
Sequence: SEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAQEVLPAIRGYVHYFFGCRDCAGHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQW | ||||||
Region | 573-638 | Disordered | ||||
Sequence: GRNSTLDPGKPEMMKSPANTTPDVPVERPEASRPPKLRPGLGAAPGQEPPEHMAELQRKEWEQPRG | ||||||
Compositional bias | 624-638 | Basic and acidic residues | ||||
Sequence: HMAELQRKEWEQPRG |
Sequence similarities
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length747
- Mass (Da)82,514
- Last updated2018-03-28 v1
- Checksum3D725C715DCE0392
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K6LK58 | A0A2K6LK58_RHIBE | QSOX1 | 604 | ||
A0A2K6LK80 | A0A2K6LK80_RHIBE | QSOX1 | 747 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 624-638 | Basic and acidic residues | ||||
Sequence: HMAELQRKEWEQPRG |
Keywords
- Technical term