A0A2K6LK76 · A0A2K6LK76_RHIBE

Function

function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular exosome
Cellular ComponentGolgi membrane
Cellular Componentintercellular bridge
Molecular FunctionFAD binding
Molecular Functionflavin-dependent sulfhydryl oxidase activity
Molecular Functionprotein disulfide isomerase activity
Biological Processextracellular matrix assembly
Biological Processnegative regulation of macroautophagy
Biological Processprotein folding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfhydryl oxidase
  • EC number

Gene names

    • Name
      QSOX1

Organism names

Accessions

  • Primary accession
    A0A2K6LK76

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane714-731Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_501438688830-747Sulfhydryl oxidase

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain36-156Thioredoxin
Domain396-503ERV/ALR sulfhydryl oxidase
Region573-638Disordered
Compositional bias624-638Basic and acidic residues

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    747
  • Mass (Da)
    82,514
  • Last updated
    2018-03-28 v1
  • Checksum
    3D725C715DCE0392
MGRCGRGSEPLPSLLLLLLLLLAVPGAGAAPRSALYSPSDPLTLLQADTVRGAVLGSRGAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALNLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFSKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNKEEYLALIFEKGGSYLGREVALDLSQHKGVTVRRVLNTEADVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKFADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAQEVLPAIRGYVHYFFGCRDCAGHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLRFLKAHFSPSNIILDFPAAGSAARREAQNVAAAPELAMGSLELEGRNSTLDPGKPEMMKSPANTTPDVPVERPEASRPPKLRPGLGAAPGQEPPEHMAELQRKEWEQPRGQWHLSKRDTGAALLAESRAEKNHLWGPSEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSHLDISLCVGLYSLSFMGLLAMYTYFRAKIRALKGHVGHPAA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6LK58A0A2K6LK58_RHIBEQSOX1604
A0A2K6LK80A0A2K6LK80_RHIBEQSOX1747

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias624-638Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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