A0A2K6LCA7 · A0A2K6LCA7_RHIBE
- Protein2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
- GeneDPH1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids345 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.
Catalytic activity
- L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H+
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Protein modification; peptidyl-diphthamide biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-(3-amino-3-carboxypropyl)histidine synthase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | protein histidyl modification to diphthamide |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Rhinopithecus
Accessions
- Primary accessionA0A2K6LCA7
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length345
- Mass (Da)38,032
- Last updated2018-03-28 v1
- MD5 Checksum2B9A3EA68337B194BEDAB21A63BE31BD
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K6LCC3 | A0A2K6LCC3_RHIBE | DPH1 | 370 |
Keywords
- Technical term