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A0A2K6LCA7 · A0A2K6LCA7_RHIBE

Function

function

Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

GO annotations

AspectTerm
Molecular Function2-(3-amino-3-carboxypropyl)histidine synthase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
  • EC number

Gene names

    • Name
      DPH1

Organism names

Accessions

  • Primary accession
    A0A2K6LCA7

Proteomes

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region299-328Disordered

Sequence similarities

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    345
  • Mass (Da)
    38,032
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    2B9A3EA68337B194BEDAB21A63BE31BD
FTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLVPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLPKEVEAVVYLGDGRFHLESVMVANPNVPAYRYDPYSKVLSREHYDHQRMRAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLQALGLSFVRLLLSEIFPSKLSLLPKVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDIPWQQPYPMDFYAGSSLGPWTVNHGLDRRPQTPGRPARGKVQEGSTHPPSAVACEDCSCRDKKVAPLAP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6LCC3A0A2K6LCC3_RHIBEDPH1370

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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