A0A2K6H0V0 · A0A2K6H0V0_PROCO
- ProteinMethylcytosine dioxygenase TET
- GeneTET3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1791 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | female pronucleus | |
Cellular Component | male pronucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | methyl-CpG binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | epigenetic programing of male pronucleus | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Indriidae > Propithecus
Accessions
- Primary accessionA0A2K6H0V0
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-90 | CXXC-type | ||||
Sequence: GRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCE | ||||||
Region | 141-165 | Disordered | ||||
Sequence: VYHGDSRQLSASGAPVNGAREPAGP | ||||||
Region | 229-250 | Disordered | ||||
Sequence: SREAGNNSGGPQPGPEGCFAGS | ||||||
Region | 298-327 | Disordered | ||||
Sequence: GEERPRLPGPLPPGEAGLPAPSTRPLRSSE | ||||||
Compositional bias | 370-384 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPL | ||||||
Region | 370-460 | Disordered | ||||
Sequence: LPQPSHSTSQASCPLPEALSPPAPFRSPQSYLQAPSWPVAPPEEHASFVPDNPAFPPATPRTEFPEAWGANTRPATPRNSWPMPRPSPDPM | ||||||
Region | 480-612 | Disordered | ||||
Sequence: RPEALPTKPKVKVEVPSSSPAPAPAPVLQREASEPDTHQKAQTALQQHLHHKRSLFLEQAHNTSFPLPSEPPAPGWWAPPSSAAPRPPDRPPKEKKKKPLTPTGGPMGMEKAAPGMKPSVRKPIQIKKSRPRE | ||||||
Compositional bias | 546-566 | Pro residues | ||||
Sequence: LPSEPPAPGWWAPPSSAAPRP | ||||||
Region | 631-703 | Disordered | ||||
Sequence: TASEEVQAPPPAPLPASQGSAVPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMATLQPGSTGPLPPADDKL | ||||||
Compositional bias | 638-662 | Pro residues | ||||
Sequence: APPPAPLPASQGSAVPLPPEPSLAL | ||||||
Compositional bias | 670-690 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMATLQP | ||||||
Region | 715-734 | Disordered | ||||
Sequence: GDSFGLPGPPSVPIQDPENQ | ||||||
Region | 1341-1386 | Disordered | ||||
Sequence: VPADTHHPAPHHQQPAYPGPKEYLLPKAPQIHPVSRDPSPFAQSSN | ||||||
Region | 1407-1427 | Disordered | ||||
Sequence: SRDPGKMGKTPLPEASQNGGP | ||||||
Region | 1601-1633 | Disordered | ||||
Sequence: PFGLEEGPNEEPPSKGAVKEEKGGGGGAEEEEE | ||||||
Compositional bias | 1612-1629 | Basic and acidic residues | ||||
Sequence: PPSKGAVKEEKGGGGGAE |
Sequence similarities
Belongs to the TET family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,791
- Mass (Da)193,402
- Last updated2018-03-28 v1
- Checksum45FDC72B702D0E7B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K6H0L7 | A0A2K6H0L7_PROCO | TET3 | 1698 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 370-384 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPL | ||||||
Compositional bias | 546-566 | Pro residues | ||||
Sequence: LPSEPPAPGWWAPPSSAAPRP | ||||||
Compositional bias | 638-662 | Pro residues | ||||
Sequence: APPPAPLPASQGSAVPLPPEPSLAL | ||||||
Compositional bias | 670-690 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMATLQP | ||||||
Compositional bias | 1612-1629 | Basic and acidic residues | ||||
Sequence: PPSKGAVKEEKGGGGGAE |
Keywords
- Technical term