A0A2K6H0V0 · A0A2K6H0V0_PROCO

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular Componentfemale pronucleus
Cellular Componentmale pronucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionmethyl-CpG binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processepigenetic programing of male pronucleus
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein O-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • Name
      TET3

Organism names

Accessions

  • Primary accession
    A0A2K6H0V0

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain50-90CXXC-type
Region141-165Disordered
Region229-250Disordered
Region298-327Disordered
Compositional bias370-384Polar residues
Region370-460Disordered
Region480-612Disordered
Compositional bias546-566Pro residues
Region631-703Disordered
Compositional bias638-662Pro residues
Compositional bias670-690Polar residues
Region715-734Disordered
Region1341-1386Disordered
Region1407-1427Disordered
Region1601-1633Disordered
Compositional bias1612-1629Basic and acidic residues

Sequence similarities

Belongs to the TET family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,791
  • Mass (Da)
    193,402
  • Last updated
    2018-03-28 v1
  • Checksum
    45FDC72B702D0E7B
MSQFQVPLAVQPDLPGLYDFPQGQVMVGGFAGPGLPMARSDPQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKASEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGAPVNGAREPAGPSLLGAGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSGGPQPGPEGCFAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLRSSEVPQIPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPPAPFRSPQSYLQAPSWPVAPPEEHASFVPDNPAFPPATPRTEFPEAWGANTRPATPRNSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEVPSSSPAPAPAPVLQREASEPDTHQKAQTALQQHLHHKRSLFLEQAHNTSFPLPSEPPAPGWWAPPSSAAPRPPDRPPKEKKKKPLTPTGGPMGMEKAAPGMKPSVRKPIQIKKSRPREAQPLFLPLRQIVLEELRSTASEEVQAPPPAPLPASQGSAVPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMATLQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQPTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKQLAPQAYQNQVTNEEVAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTSFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGIPTDPGLSLKGGLSQQSLKPSLKVEPQNHFSSFKYSSNSVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLAPVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSNGSFEKKPDLHTLHNSLSPAYGGAEFAELPSQAVPADTHHPAPHHQQPAYPGPKEYLLPKAPQIHPVSRDPSPFAQSSNCYNRSIKQEPVDPLIQAESVSRDPGKMGKTPLPEASQNGGPSHLWGQYTGGPSLSPKRTNSVSGSWGVFPSGESPAIVPDKLSSFGASCLTPSHFSDGQWGLFPGEGQQSSPHPGGRLRGKPWSPCKFGNNTSALAGPGLTEKPWGLGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPTPGASQLDKAWQSFGMPLGSSEKLFGALKSEEKLWDPFGLEEGPNEEPPSKGAVKEEKGGGGGAEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAEKARVQQEAAARLGLGQQEAKLYGKKRKWGGAVVSEPQHKEKKGFVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6H0L7A0A2K6H0L7_PROCOTET31698

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias370-384Polar residues
Compositional bias546-566Pro residues
Compositional bias638-662Pro residues
Compositional bias670-690Polar residues
Compositional bias1612-1629Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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