A0A2K6GGK7 · A0A2K6GGK7_PROCO
- ProteinGeneral transcription and DNA repair factor IIH helicase/translocase subunit XPB
- GeneERCC3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids782 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGeneral transcription and DNA repair factor IIH helicase/translocase subunit XPB
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Indriidae > Propithecus
Accessions
- Primary accessionA0A2K6GGK7
Proteomes
Subcellular Location
Interaction
Subunit
Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. Interacts with ATF7IP. Interacts with KAT2A; leading to KAT2A recruitment to promoters and acetylation of histones. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-22 | Basic and acidic residues | |||
Region | 1-55 | Disordered | |||
Compositional bias | 220-240 | Polar residues | |||
Region | 220-242 | Disordered | |||
Domain | 327-488 | Helicase ATP-binding | |||
Domain | 542-702 | Helicase C-terminal | |||
Sequence similarities
Belongs to the helicase family. RAD25/XPB subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length782
- Mass (Da)89,147
- Last updated2018-03-28 v1
- MD5 Checksum5A94C812E9A54F601DA5729BB12C5037
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-22 | Basic and acidic residues | |||
Compositional bias | 220-240 | Polar residues | |||
Keywords
- Technical term