A0A2K6GGC7 · A0A2K6GGC7_PROCO

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, site.

145650100150200250300350400450
TypeIDPosition(s)Description
Binding site230-235strychnine (UniProtKB | ChEBI)
Site289Important for obstruction of the ion pore in the closed conformation

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloride channel complex
Cellular Componentdendrite
Cellular Componentexternal side of plasma membrane
Cellular Componentglycinergic synapse
Cellular Componentinhibitory synapse
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentperikaryon
Cellular Componentpostsynaptic membrane
Molecular Functionextracellularly glycine-gated chloride channel activity
Molecular Functionglycine binding
Molecular Functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Molecular Functiontaurine binding
Molecular Functiontransmembrane signaling receptor activity
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Molecular Functionzinc ion binding
Biological Processacrosome reaction
Biological Processadult walking behavior
Biological Processcellular response to amino acid stimulus
Biological Processcellular response to ethanol
Biological Processcellular response to zinc ion
Biological Processinhibitory postsynaptic potential
Biological Processmuscle contraction
Biological Processnegative regulation of transmission of nerve impulse
Biological Processneuromuscular process controlling posture
Biological Processneuronal action potential
Biological Processneuropeptide signaling pathway
Biological Processpositive regulation of acrosome reaction
Biological Processregulation of respiratory gaseous exchange by nervous system process
Biological Processrighting reflex
Biological Processstartle response
Biological Processsynaptic transmission, glycinergic
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Glycine receptor alpha 1

Gene names

    • Name
      GLRA1

Organism names

Accessions

  • Primary accession
    A0A2K6GGC7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane250-272Helical
Transmembrane313-336Helical
Transmembrane428-448Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_502225033529-456
Disulfide bond166↔180
Disulfide bond226↔237

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain43-248Neurotransmitter-gated ion-channel ligand-binding
Domain255-377Neurotransmitter-gated ion-channel transmembrane
Region388-410Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    52,519
  • Last updated
    2018-03-28 v1
  • Checksum
    5E9731E9CE352A4E
MYSFNSLRLYLWETIVLFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGLSVKGTNNNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6GGE1A0A2K6GGE1_PROCOGLRA1363
A0A2K6GGB5A0A2K6GGB5_PROCOGLRA1451

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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