A0A2K6ES63 · A0A2K6ES63_PROCO
- Protein3-hydroxyanthranilate 3,4-dioxygenase
- GeneHAAO
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids286 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Catalytic activity
- 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
Cofactor
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 43 | O2 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 47 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 53 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 53 | substrate | ||||
Sequence: E | ||||||
Binding site | 91 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 95 | substrate | ||||
Sequence: R | ||||||
Binding site | 105 | substrate | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3-hydroxyanthranilate 3,4-dioxygenase activity | |
Molecular Function | ferrous iron binding | |
Biological Process | 'de novo' NAD biosynthetic process from tryptophan | |
Biological Process | anthranilate metabolic process | |
Biological Process | neuron cellular homeostasis | |
Biological Process | quinolinate biosynthetic process | |
Biological Process | response to cadmium ion | |
Biological Process | response to zinc ion | |
Biological Process | tryptophan catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxyanthranilate 3,4-dioxygenase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Indriidae > Propithecus
Accessions
- Primary accessionA0A2K6ES63
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-203 | Domain A (catalytic) | ||||
Sequence: MQRPVAVRSWVEENRASFLPPVCNKLMHQEQLKIMFVGGPNTRKDYHIEEGEEVFCQLEGDMVLRVLERGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVIERRRLETELDGLRYYMGDTTDVLFEKWFYCKDLGTQLAPIIQEFFNSEQCRTGKPIPDQLLKKPPFPLSTRSIMEPMSLEAWLDGHRRELQAGTPLSLF | ||||||
Region | 203-286 | Domain B | ||||
Sequence: FGDTYETKVIAHGQGSSKVSRQDVDVWLWQLEGSSVVTMEGQRLSLNPDASLLVPAGTSYAWERARGSVALSVTQDPACKKPLG |
Sequence similarities
Belongs to the 3-HAO family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length286
- Mass (Da)32,480
- Last updated2018-03-28 v1
- ChecksumC6F7EAF03D41F9F3
Keywords
- Technical term