A0A2K6ES63 · A0A2K6ES63_PROCO

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site43O2 (UniProtKB | ChEBI)
Binding site47Fe cation (UniProtKB | ChEBI); catalytic
Binding site53Fe cation (UniProtKB | ChEBI); catalytic
Binding site53substrate
Binding site91Fe cation (UniProtKB | ChEBI); catalytic
Binding site95substrate
Binding site105substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processneuron cellular homeostasis
Biological Processquinolinate biosynthetic process
Biological Processresponse to cadmium ion
Biological Processresponse to zinc ion
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase
      (3-HAO
      )
    • 3-hydroxyanthranilic acid dioxygenase
      (HAD
      )

Gene names

    • Name
      HAAO

Organism names

Accessions

  • Primary accession
    A0A2K6ES63

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-203Domain A (catalytic)
Region203-286Domain B

Sequence similarities

Belongs to the 3-HAO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    32,480
  • Last updated
    2018-03-28 v1
  • Checksum
    C6F7EAF03D41F9F3
MQRPVAVRSWVEENRASFLPPVCNKLMHQEQLKIMFVGGPNTRKDYHIEEGEEVFCQLEGDMVLRVLERGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVIERRRLETELDGLRYYMGDTTDVLFEKWFYCKDLGTQLAPIIQEFFNSEQCRTGKPIPDQLLKKPPFPLSTRSIMEPMSLEAWLDGHRRELQAGTPLSLFGDTYETKVIAHGQGSSKVSRQDVDVWLWQLEGSSVVTMEGQRLSLNPDASLLVPAGTSYAWERARGSVALSVTQDPACKKPLG

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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