A0A2K6AFA0 · A0A2K6AFA0_MANLE

Function

function

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchylomicron
Cellular Componentintermediate-density lipoprotein particle
Cellular Componentlow-density lipoprotein particle
Cellular Componentspherical high-density lipoprotein particle
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionlipase inhibitor activity
Molecular Functionlipid binding
Molecular Functionlipoprotein lipase activator activity
Molecular Functionphospholipase activator activity
Molecular Functionphospholipase binding
Biological Processcholesterol efflux
Biological Processchylomicron remnant clearance
Biological Processhigh-density lipoprotein particle clearance
Biological Processlipid catabolic process
Biological Processnegative regulation of cholesterol transport
Biological Processnegative regulation of lipid metabolic process
Biological Processnegative regulation of receptor-mediated endocytosis
Biological Processnegative regulation of very-low-density lipoprotein particle clearance
Biological Processphospholipid efflux
Biological Processpositive regulation of fatty acid biosynthetic process
Biological Processpositive regulation of lipoprotein lipase activity
Biological Processpositive regulation of phospholipase activity
Biological Processpositive regulation of phospholipid catabolic process
Biological Processpositive regulation of triglyceride catabolic process
Biological Processtriglyceride homeostasis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apolipoprotein C-II
  • Short names
    Apo-CII
    ; ApoC-II
  • Alternative names
    • Apolipoprotein C2

Gene names

    • Name
      APOC2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Mandrillus

Accessions

  • Primary accession
    A0A2K6AFA0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_501443467818-72Apolipoprotein C-II

Post-translational modification

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the apolipoprotein C2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    72
  • Mass (Da)
    8,038
  • Last updated
    2018-03-28 v1
  • Checksum
    F893A91EDB3FC1F2
MGTRFLLALCLVLLVLGFEVQGAQLPQQDERPSPALLSQVQESLSSYWESAKAAAQKLYEKTYLPAVDEKLR

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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