A0A2K5X4Y9 · A0A2K5X4Y9_MACFA
- ProteinMultidrug resistance-associated protein 1
- GeneABCC1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1528 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
- leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | lateral plasma membrane | |
Molecular Function | ABC-type glutathione S-conjugate transporter activity | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATPase-coupled lipid transmembrane transporter activity | |
Molecular Function | carboxylic acid transmembrane transporter activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | glutathione transmembrane transporter activity | |
Biological Process | cyclic nucleotide transport | |
Biological Process | export across plasma membrane | |
Biological Process | phospholipid translocation | |
Biological Process | sphingolipid translocation | |
Biological Process | transepithelial transport | |
Biological Process | xenobiotic transport across blood-brain barrier |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug resistance-associated protein 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5X4Y9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 45-64 | Helical | ||||
Sequence: VLVWVPCFYLWACFPFYFLY | ||||||
Transmembrane | 84-102 | Helical | ||||
Sequence: ALGFLLWIVCWADLFYSFW | ||||||
Transmembrane | 108-132 | Helical | ||||
Sequence: IFLAPVFLVSPTLLGITMLLATFLI | ||||||
Transmembrane | 144-161 | Helical | ||||
Sequence: GIMLTFWLVALLCALAIL | ||||||
Transmembrane | 181-199 | Helical | ||||
Sequence: MTFYVYFSLVLIQLVLSCF | ||||||
Transmembrane | 324-342 | Helical | ||||
Sequence: VLYKTFGPYFLMSFFFKAI | ||||||
Transmembrane | 372-393 | Helical | ||||
Sequence: YFYTALLFVAACLQTLVLHQYF | ||||||
Transmembrane | 434-456 | Helical | ||||
Sequence: LATYINMIWSAPLQVILALYLLW | ||||||
Transmembrane | 462-482 | Helical | ||||
Sequence: PILAGVAVMVLMVPVNAVMAM | ||||||
Transmembrane | 540-568 | Helical | ||||
Sequence: AYLAAVGTFTWVCTPFLVALCTFAVYVTI | ||||||
Transmembrane | 580-604 | Helical | ||||
Sequence: FVSLALFNILRFPLNILPMVISSIV | ||||||
Transmembrane | 966-993 | Helical | ||||
Sequence: AIGLFISFLSIFLFICNHVAALASNYWL | ||||||
Transmembrane | 1013-1041 | Helical | ||||
Sequence: LSVYGALGISQGIAVFGYSMAVSIGGILA | ||||||
Transmembrane | 1098-1126 | Helical | ||||
Sequence: VIGACIVILLATPIAAIIIPPLGLIYFFV | ||||||
Transmembrane | 1196-1217 | Helical | ||||
Sequence: LAVRLECVGNCIVLFAALFAVI | ||||||
Transmembrane | 1224-1245 | Helical | ||||
Sequence: AGLVGLSVSYSLQVTTYLNWLV |
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 334-605 | ABC transmembrane type-1 | ||||
Sequence: LMSFFFKAIHDLMMFSGPEILKLLINFVNDTKAPDWQGYFYTALLFVAACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKVGGAVQKILMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPPILAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALCTFAVYVTIDKNNVLDAQKAFVSLALFNILRFPLNILPMVISSIVQ | ||||||
Domain | 641-865 | ABC transporter | ||||
Sequence: ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLQENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT | ||||||
Region | 868-890 | Disordered | ||||
Sequence: SAEQEQDPEDNGVTGVSGPGKEA | ||||||
Compositional bias | 914-929 | Polar residues | ||||
Sequence: SSSYSGDVSRQHNSTA | ||||||
Region | 914-935 | Disordered | ||||
Sequence: SSSYSGDVSRQHNSTAELQKDG | ||||||
Domain | 973-1253 | ABC transmembrane type-1 | ||||
Sequence: FLSIFLFICNHVAALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRYLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET | ||||||
Domain | 1290-1524 | ABC transporter | ||||
Sequence: VEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIARIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYNMARD |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,528
- Mass (Da)171,372
- Last updated2021-06-02 v2
- Checksum935C845599AA68D8
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5X4Y2 | A0A2K5X4Y2_MACFA | ABCC1 | 1477 | ||
A0A2K5X4E9 | A0A2K5X4E9_MACFA | ABCC1 | 1400 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 914-929 | Polar residues | ||||
Sequence: SSSYSGDVSRQHNSTA |
Keywords
- Technical term