A0A2K5X4Y9 · A0A2K5X4Y9_MACFA

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
  • leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentlateral plasma membrane
Molecular FunctionABC-type glutathione S-conjugate transporter activity
Molecular FunctionABC-type xenobiotic transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATPase-coupled lipid transmembrane transporter activity
Molecular Functioncarboxylic acid transmembrane transporter activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionglutathione transmembrane transporter activity
Biological Processcyclic nucleotide transport
Biological Processexport across plasma membrane
Biological Processphospholipid translocation
Biological Processsphingolipid translocation
Biological Processtransepithelial transport
Biological Processxenobiotic transport across blood-brain barrier

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multidrug resistance-associated protein 1
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 1
    • Glutathione-S-conjugate-translocating ATPase ABCC1
    • Leukotriene C(4) transporter

Gene names

    • Name
      ABCC1

Organism names

Accessions

  • Primary accession
    A0A2K5X4Y9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane45-64Helical
Transmembrane84-102Helical
Transmembrane108-132Helical
Transmembrane144-161Helical
Transmembrane181-199Helical
Transmembrane324-342Helical
Transmembrane372-393Helical
Transmembrane434-456Helical
Transmembrane462-482Helical
Transmembrane540-568Helical
Transmembrane580-604Helical
Transmembrane966-993Helical
Transmembrane1013-1041Helical
Transmembrane1098-1126Helical
Transmembrane1196-1217Helical
Transmembrane1224-1245Helical

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain334-605ABC transmembrane type-1
Domain641-865ABC transporter
Region868-890Disordered
Compositional bias914-929Polar residues
Region914-935Disordered
Domain973-1253ABC transmembrane type-1
Domain1290-1524ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,528
  • Mass (Da)
    171,372
  • Last updated
    2021-06-02 v2
  • Checksum
    935C845599AA68D8
ILKQGLCCSGGSSEGTTYLYPLFLDWNVTWYTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTLLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIMTALKEDVQVDLFRDMTFYVYFSLVLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKDSSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPEILKLLINFVNDTKAPDWQGYFYTALLFVAACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKVGGAVQKILMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPPILAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALCTFAVYVTIDKNNVLDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGDTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLQENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASAEQEQDPEDNGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDVSRQHNSTAELQKDGAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFICNHVAALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRYLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSNWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIARIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYNMARDAGLV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5X4Y2A0A2K5X4Y2_MACFAABCC11477
A0A2K5X4E9A0A2K5X4E9_MACFAABCC11400

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias914-929Polar residues

Keywords

Genome annotation databases

Similar Proteins

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