A0A2K5X3B6 · ST1C4_MACFA
- ProteinSulfotransferase 1C4
- GeneSULT1C4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids302 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds and estrogen (E2) (PubMed:31100221).
Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (By similarity).
Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (By similarity).
Catalytic activity
- 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H+This reaction proceeds in the forward direction.
- 17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H+This reaction proceeds in the forward direction.
- 3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 55-60 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: KAGTTW | ||||||
Binding site | 113-115 | substrate | ||||
Sequence: KTH | ||||||
Active site | 115 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 137 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 145 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 200 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 234-239 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: TSFDVM | ||||||
Binding site | 262-266 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: FMRKG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aryl sulfotransferase activity | |
Molecular Function | sulfotransferase activity | |
Biological Process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
Biological Process | flavonoid metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfotransferase 1C4
- EC number
- Short namesST1C4
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5X3B6
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000453622 | 1-302 | Sulfotransferase 1C4 | |||
Sequence: TALHKMEDFTFDGTKRLSVNYVKGILQPTVTCDIWDEIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEWKIPSLGSGLEQAQAMPSPRILKTHLPFHLLPPSFLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPDPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEVQKLTEFIEKKLDDKVLDKIVHYTSFDVMKQNSMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMADTRLTFHFQF |
Expression
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)35,660
- Last updated2021-09-29 v3
- Checksum17EE35A25D3D53B4
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7N9IF17 | A0A7N9IF17_MACFA | SULT1C4 | 227 | ||
A0A7N9D4D7 | A0A7N9D4D7_MACFA | SULT1C4 | 302 | ||
A0A2K5X358 | A0A2K5X358_MACFA | SULT1C4 | 297 | ||
A0A8P8WY50 | A0A8P8WY50_MACFA | SULT1C4 | 347 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AQIA01016952 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |