A0A2K5WPH2 · A0A2K5WPH2_MACFA

Function

Catalytic activity

  • (E)-4-hydroxynon-2-enal + NAD+ + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 13-cis-retinal + NAD+ + H2O = 13-cis-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 3-deoxyglucosone + NAD+ + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.19 (UniProtKB | ENZYME | Rhea)
  • 9-cis-retinal + NAD+ + H2O = 9-cis-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • propanal + NAD+ + H2O = propanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • malonaldehyde + NAD+ + H2O = 3-oxopropanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.36 (UniProtKB | ENZYME | Rhea)
  • an aldehyde + NAD+ + H2O = a carboxylate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • benzaldehyde + NAD+ + H2O = benzoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.28 (UniProtKB | ENZYME | Rhea)

Pathway

Cofactor metabolism; retinol metabolism.

Keywords

  • Ligand
    • #NAD

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde dehydrogenase 1A1
  • EC number
  • Alternative names
    • 3-deoxyglucosone dehydrogenase
    • ALDH-E1
    • ALHDII
    • Aldehyde dehydrogenase family 1 member A1
    • Aldehyde dehydrogenase, cytosolic
    • Retinal dehydrogenase 1

Gene names

    • Name
      ALDH1A1

Organism names

Accessions

  • Primary accession
    A0A2K5WPH2

Proteomes

Organism-specific databases

Expression

Gene expression databases

Interaction

Subunit

Homotetramer. Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-168Aldehyde dehydrogenase
Domain174-289Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    33,132
  • Last updated
    2018-03-28 v1
  • Checksum
    8866C197986449E6
MSSSGKPDLPVLPTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPVSPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q4R5G3Q4R5G3_MACFAALDH1A1501
A0A7N9ICN8A0A7N9ICN8_MACFAALDH1A1481
A0A7N9C970A0A7N9C970_MACFAALDH1A1495
A0A7N9CC80A0A7N9CC80_MACFAALDH1A1527
A0A7N9CLZ3A0A7N9CLZ3_MACFAALDH1A1463
A0A2K5WP74A0A2K5WP74_MACFAALDH1A1230
A0A7N9CZ59A0A7N9CZ59_MACFAALDH1A1511

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp