A0A2K5WPH2 · A0A2K5WPH2_MACFA
- ProteinAldehyde dehydrogenase 1A1
- GeneALDH1A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (E)-4-hydroxynon-2-enal + NAD+ + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H+This reaction proceeds in the forward direction.
- 13-cis-retinal + NAD+ + H2O = 13-cis-retinoate + NADH + 2 H+This reaction proceeds in the forward direction.
- 3-deoxyglucosone + NAD+ + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + 2 H+This reaction proceeds in the forward direction.
- 9-cis-retinal + NAD+ + H2O = 9-cis-retinoate + NADH + 2 H+This reaction proceeds in the forward direction.
- propanal + NAD+ + H2O = propanoate + NADH + 2 H+This reaction proceeds in the forward direction.
- hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+This reaction proceeds in the forward direction.
- malonaldehyde + NAD+ + H2O = 3-oxopropanoate + NADH + 2 H+This reaction proceeds in the forward direction.
Pathway
Cofactor metabolism; retinol metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | benzaldehyde dehydrogenase (NAD+) activity |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldehyde dehydrogenase 1A1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5WPH2
Proteomes
Organism-specific databases
Expression
Gene expression databases
Interaction
Subunit
Homotetramer. Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-168 | Aldehyde dehydrogenase | ||||
Sequence: WHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIP | ||||||
Domain | 174-289 | Aldehyde dehydrogenase | ||||
Sequence: NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)33,132
- Last updated2018-03-28 v1
- Checksum8866C197986449E6
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q4R5G3 | Q4R5G3_MACFA | ALDH1A1 | 501 | ||
A0A7N9ICN8 | A0A7N9ICN8_MACFA | ALDH1A1 | 481 | ||
A0A7N9C970 | A0A7N9C970_MACFA | ALDH1A1 | 495 | ||
A0A7N9CC80 | A0A7N9CC80_MACFA | ALDH1A1 | 527 | ||
A0A7N9CLZ3 | A0A7N9CLZ3_MACFA | ALDH1A1 | 463 | ||
A0A2K5WP74 | A0A2K5WP74_MACFA | ALDH1A1 | 230 | ||
A0A7N9CZ59 | A0A7N9CZ59_MACFA | ALDH1A1 | 511 |
Keywords
- Technical term